Registration Dossier
Registration Dossier
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EC number: 202-185-5 | CAS number: 92-74-0
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1977
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Short report, available, early study, non GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Report date:
- 1977
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- 6 animals used
- GLP compliance:
- no
- Remarks:
- pre dates GLP
Test material
- Reference substance name:
- Naphtol AS-PH
- IUPAC Name:
- Naphtol AS-PH
- Reference substance name:
- 2'-ethoxy-3-hydroxy-2-naphthanilide
- EC Number:
- 202-185-5
- EC Name:
- 2'-ethoxy-3-hydroxy-2-naphthanilide
- Cas Number:
- 92-74-0
- Molecular formula:
- C19H17NO3
- IUPAC Name:
- N-(2-ethoxyphenyl)-3-hydroxynaphthalene-2-carboxamide
Constituent 1
Constituent 2
Test animals / tissue source
- Species:
- rabbit
- Strain:
- Himalayan
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- 100 mg
- Duration of treatment / exposure:
- 24 h
- Observation period (in vivo):
- 72 h
- Number of animals or in vitro replicates:
- 6
Results and discussion
In vivo
Results
- Irritation parameter:
- maximum mean total score (MMTS)
- Basis:
- mean
- Time point:
- other: 7 h
- Score:
- ca. 20
- Reversibility:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- slightly irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- Naphtol AS PH was slightly irritant in the rabbit eye.
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