Propylamine

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

12. Jan 1978 - 23. Mar 1978

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Acceptable well documented report which meets basic scientific principles.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1978

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Principles of method if other than guideline:

BASF-Test, see details in remarks on material and methods.

GLP compliance:

no

Test type:

acute toxic class method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Propylamine

EC Number:

203-462-3

EC Name:

Propylamine

Cas Number:

107-10-8

Molecular formula:

C3H9N

IUPAC Name:

propan-1-amine

Details on test material:

- Name of test material (as cited in study report): Propylamin

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Weight at study initiation: male: 218 g (mean); female: 172 g (mean)
- Diet: Alleinfutter fuer die Haltung von Maeusen, Ratten und Hamstern, Heinrich Eggersmann, Rinteln, ad libitum

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

water

Doses:

147, 215, 316, 464, 1000 mg/kg bw

No. of animals per sex per dose:

5 males, 5 females per dose

Control animals:

not specified

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: observations daily; weighing on days 3, 7, and 13
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

ca. 370 mg/kg bw

Mortality:

see details in table in remarks on results.

Clinical signs:

other: 1000 mg/kg bw: 15 min past application: dyspnoea, irregular respiration. 30 min past application: spastic gait, ruffled fur. 1 h past application: staggering, apathy. 2 h past application: lateral-abdominal position, exophthalmia 464 mg/kg bw: 15 min pa

Gross pathology:

Animals that died during the study (316, 464 and 1000 mg/kg bw):
Heart: acute dilatation of the right ventricle; acute congestion;
Lung: some animals with slight acute distensions;
Stomach: strong diffuse erythema in the glandular stomach;
Intestine: atonic, strong erythema of the mucosa; bloody diarrhetic content.

Sacrificed animals: stomach: boutons in the forestomach, agglutination of the forestomach with the peritoneum.

Sacrificed animals (316, 215, 147 mg/kg bw):
No abnormalities were observed.

Any other information on results incl. tables

Mortality:

Dose (mg/kg bw)	Gender	1 h	24 h	48 h	7 days	14 days
1000	male	0/5	5/5	5/5	5/5	5/5
	female	1/5	5/5	5/5	5/5	5/5
464	male	0/5	3/5	3/5	4/5	4/5
	female	0/5	2/5	2/5	5/5	5/5
316	male	0/5	0/5	1/5	2/5	2/5
	female	0/5	0/5	0/5	0/5	0/5
215	male	0/5	0/5	0/5	0/5	0/5
	female	0/5	0/5	0/5	0/5	0/5
147	male	0/5	0/5	0/5	0/5	0/5
	female	0/5	0/5	0/5	0/5	0/5

Weight:

Dose (mg/kg)	Gender	0 h	3 days	7 days	14 days
1000	male	180	-	-	-
	female	160	-	-	-
464	male	210	187	200	245
	female	160	-	-	-
316	male	230	220	252	277
	female	190	185	213	224
215	male	240	239	264	291
	female	160	158	178	186
147	male	230	228	266	263
	female	190	197	219	230

The test substance caused systemic toxicity (including mortality) and local irritation in a dose dependent manner.