Registration Dossier
Registration Dossier
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EC number: 231-154-9 | CAS number: 7440-45-1
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Pharmacology and toxicology of the rare earth elements
- Author:
- Haley T.J.
- Year:
- 1 965
- Bibliographic source:
- Journal of pharmaceutical sciences
Materials and methods
- Principles of method if other than guideline:
- The acute lethal doses of the cerium compounds, as published in diverse scientific publications, have been reviewed.
Test material
- Reference substance name:
- Cerium
- EC Number:
- 231-154-9
- EC Name:
- Cerium
- Cas Number:
- 7440-45-1
- Molecular formula:
- Ce
- IUPAC Name:
- cerium(3+)
- Details on test material:
- Cerium compounds: cerium chloride, cerium citrate chloride, cerium nitrate
Constituent 1
Test animals
- Species:
- other: frog, mouse, rat, guinea pig
Administration / exposure
- Route of administration:
- other: subcutaneous, intraperitoneal, intravenous, oral
Results and discussion
Any other information on results incl. tables
This review collects the LD50 values of cerium compounds as applied to diversed animal species:
Chemical |
Species, sex |
LD50 (mg/Kg) |
Administration |
Reference |
Cerium chloride |
Frog |
About 300 |
Subcutaneous |
Hara S, Arch. Expil. Pathol Pharmakol 100, 230 (1923) |
|
Mouse |
5.000 – 10.000 |
subcutaneous |
Ibid, 100, 217 (1923) |
|
Mouse |
296 – 420 |
intraperitoneal |
Graca JG, Garst EL, Lowry W, A.M.A.Health 15, 9 (1957) |
|
Rat |
2.000 – 4.000 |
subcutaneous |
Ibid, 100, 217 (1923) |
|
Rat |
50– 60 |
intravenous |
Maxwll LC, Bischoff F, J. Pharmacol. Expil Therap. 43, 61 (1931) |
|
Guinea pig |
40 – 77 |
Intraperitoneal |
Graca JG, Garst EL, Lowry W, A.M.A.Health 15, 9 (1957) |
Cerium citrate chloride |
Rat |
128 – 167 |
Intraperitoneal |
Graca JG, Garst EL, Lowry W, A.M.A.Health 15, 9 (1957) |
|
Guinea pig |
73 – 146 |
Intraperitoneal |
Graca JG, Garst EL, Lowry W, A.M.A.Health 15, 9 (1957) |
Cerium nitrat |
Mouse, female |
435 – 508 |
Intraperitoneal |
Bruce DW, Hietbrink BE, BuBois KP, Toxicol. Appl. Pharmacol, 5, 750 (1963) |
|
Rat, female |
238 – 354 |
Intraperitoneal |
Bruce DW, Hietbrink BE, BuBois KP, Toxicol. Appl. Pharmacol, 5, 750 (1963) |
|
Rat, female |
3.684 – 4.788 |
oral |
Bruce DW, Hietbrink BE, BuBois KP, Toxicol. Appl. Pharmacol, 5, 750 (1963) |
|
Rat, female |
3,4 - 5,6 |
intravenous |
Bruce DW, Hietbrink BE, BuBois KP, Toxicol. Appl. Pharmacol, 5, 750 (1963) |
|
Rat, male |
32,8 – 74,4 |
intravenous |
Bruce DW, Hietbrink BE, BuBois KP, Toxicol. Appl. Pharmacol, 5, 750 (1963) |
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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