Registration Dossier
Registration Dossier
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EC number: 219-342-9 | CAS number: 2420-87-3
Endpoint summary
Administrative data
Description of key information
In the acute immobilization test with Daphnia magna (STRAUS), the effects of the test item were determined according to OECD 202 (2004). The study was conducted under semi-static conditions over a period of 48 hours with a saturated solution (prepared with a nominal concentration of 100 mg/L of the test item and further four dilution levels in a geometric series with a separation factor of 2 (nominal concentrations of 6.25 to 100% of the saturated solution). The measured concentrations of the saturated solution were 30.1 mg/L at 0 hours and 25.0 mg/L at 24 hours. The measured concentrations of the test item at the start of the exposure intervals (0 and 24 hours) reflect the dilution factor of 2. At the end of the exposure intervals (24 and 48 hours), the measured concentrations were within the range of 85 to 135% of the initially measured concentrations.The effect values are based on the geometric mean measured concentrations of the test item. In this study, no biological effects occurred in the saturated solution with a geometric mean measured concentration of 28.1 mg/L. Thus, the test item is not toxic up to the limit of water solubility.
The validity criteria of the test guidelines were fulfilled.
The toxicity of the test item to the unicellular freshwater green alga Pseudokirchneriella subcapitata was determined according to the principles of OECD 201 and Council Regulation (EC) No. 761/2009/Method C.3.
The study was conducted under static conditions with an initial cell density of 6305 cells/mL. A saturated solution of 100 mg/L was prepared and five dilution levels were tested in a geometrical series with a dilution factor of 2.5. The concentrations of the test item in all test concentrations and the control were analytically verified by LC-MS/MS at the start (0 hours) and at the end (72 hours) of the exposure.The measured concentrations in the fresh media (0 h) were in the range of 0.523 to 20.1 mg test item/L. The measured concentrations in the old media (72 h) were in the range of 0.482 to 18.3 mg test item/L.
All effect values are based on the geometric mean measured test item concentrations of the test item. The EC50 based on growth rate is 19.2 mg/L and the NOEC based on growth rate 3.19 mg/L
Additional information
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