4,6-Pyrimidinediamine, 2-[5-fluoro-1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-[(1E)-2-phenyldiazenyl]-

Vapour pressure

Administrative data

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2019-03-11 to 2019-03-20

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2019

Report date:

2019

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

Version / remarks:

OECD Guidelines for the Testing of Chemicals No. 104: "Vapour Pressure", March 23, 2006

Test guideline 2

Qualifier:

according to guideline

Guideline:

EU Method A.4 (Vapour Pressure)

Version / remarks:

EC No. 761/2009, Part A: Methods for Determination of Physico-Chemical Properties, Guideline A.4: “Vapour Pressure”, Official Journal of the European Union No. L220, August 24, 2009

GLP compliance:

no

Type of method:

effusion method: isothermal thermogravimetry

Test material

Test material information

Constituent 1

Reference substance name:

2-{5-fluoro-1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl}-5-[(1E)-2-phenyldiazen-1-yl]pyrimidine-4,6-diamine

EC Number:

811-933-5

Cas Number:

1350653-29-0

Molecular formula:

C23 H17 F2 N9

IUPAC Name:

2-{5-fluoro-1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl}-5-[(1E)-2-phenyldiazen-1-yl]pyrimidine-4,6-diamine

Test material form:

solid

Results and discussion

Vapour pressure

Key result

Test no.:

#1

Temp.:

20 °C

Vapour pressure:

ca. 0 Pa

Remarks on result:

other: The vapour pressure of the test item was estimated to be below 10-10 Pa at 20 °C (6.03 x 10^-13 Pa).

Any other information on results incl. tables

The isothermal thermogravimetrical effusion method was applied for the determination of the vapour pressure of Fluorazopyrimidin.

A value of the vapour pressure of the test item was determined using the data obtained between 250 °C and 280 °C. The vapour pressure of the test item was estimated to be below 10^-10 Pa at 20 °C (6.03 x 10^-13 Pa).

Applicant's summary and conclusion

Conclusions:

The isothermal thermogravimetrical effusion method was applied for the determination of the vapour pressure of Fluorazopyrimidin.
A value of the vapour pressure of the test item was determined using the data obtained between 250 °C and 280 °C. The vapour pressure of the test item was estimated to be below 10-10 Pa at 20 °C (6.03 x 10-13 Pa).

Executive summary:

Title:

Fluorazopyrimidin: Determination of the Vapour Pressure by Isothermal Thermogravimetry

 

Purpose:

The purpose of this study was to determine the vapour pressure of the test item using the isothermal thermogravimetrical effusion method.

 

Guidelines / Recommendations:

This study was designed to comply with the following methods:

European Community (EC), EC No. 761/2009, A.4: “Vapour Pressure”, 2009

Organisation for Economic Co-operation and Development (OECD), OECD Guidelines for the Testing of Chemicals No. 104: “Vapour Pressure”, 2006

 

Results / Conclusion:

The isothermal thermogravimetrical effusion method was applied for the determination of the vapour pressure of Fluorazopyrimidin.

A value of the vapour pressure of the test item was determined using the data obtained between 250 °C and 280 °C. The vapour pressure of the test item was estimated to be below 10-10 Pa at 20 °C (6.03 x 10-13 Pa).

This study is classified acceptable and satisfies the guideline requirements for vapour pressure studies.