(3-aminophenyl)urea

Endpoint summary

Description of key information

Short term toxicity to fish

Using the EPI Suite ECOSAR version 1.11, the short term toxicity on fish was predicted for test substance  1-(3-aminophenyl)urea (CAS:25711-72-2) on the basis of effects observed in a static freshwater system. The lethal concentration LC50 value for the substance was estimated to be 37434.19 mg/l in fish for 96 hr duration. Based on this value it can be concluded that the 1-(3-aminophenyl)urea   (CAS:25711-72-2) is likely to be non-toxic to aquatic environment and can be considered as not classified as per the CLP classification criteria.

Short term toxicity on aquatic invertebrates

Using the OECD QSAR toolbox version 3.3 with log kow as the primary descriptor and considering the five closest read across substances, the short term toxicity on aquatic invertebrates was predicted for 1-(3-aminophenyl)urea (25711-72-2). EC50 value was estimated to be 184.58 mg/l for Daphnia magna for 48 hrs duration.

Short term toxicity on aquatic algae and cyanobacteria

Using the OECD QSAR toolbox version 3.3 with log kow as the primary descriptor and considering the five closest read across substances, the short term toxicity on aquatic algae and cyanobacteria was predicted for target substance 1-(3-aminophenyl)urea (25711-72-2). EC50 value was estimated to be 103.62 mg/l for Pseudokirchneriella subcapitata for 72 h duration.

Additional information

Short term toxicity to fish

Using the EPI Suite ECOSAR version 1.11, the short term toxicity on fish was predicted for test substance  1-(3-aminophenyl)urea (CAS:25711-72-2) on the basis of effects observed in a static freshwater system. The lethal concentration LC50 value for the substance was estimated to be 37434.19 mg/l in fish for 96 hr duration. Based on this value it can be concluded that the 1-(3-aminophenyl)urea   (CAS:25711-72-2) is likely to be non-toxic to aquatic environment and can be considered as not classified as per the CLP classification criteria.

Short term toxicity to aquatic invertebrates

Short term toxicity to aquatic invertebrates for 1-(3-aminophenyl)urea (25711-72-2) was summarised with predicted data for target and by using structural read across studies as follows:

Using the OECD QSAR toolbox version 3.3 with log kow as the primary descriptor and considering the five closest read across substances, the short term toxicity on aquatic invertebrates was predicted for 1-(3-aminophenyl)urea (25711-72-2). EC50 value was estimated to be 184.58 mg/l for Daphnia magna for 48 hrs duration.

In another prediction done by EPI suite, ECOSAR version 1.1, on the basis of similarity of structure to chemicals for which the aquatic toxicity has been previously measured by structure-activity relationships (SARs) program, the LC 50 value for short term toxicity to aquatic invertebrates was predicted. On the basis of this program, the LC 50 value for short term toxicity to aquatic invertebrates was predicted to be 16472.984 mg/l for 1-(3-aminophenyl)urea in 48 hrs.

Short term toxicity to aquatic invertebrates (Ecotox database, 2017) for read across 4-amino-N-(4-methylpyrimidin-2-yl)benzene sulfonamide(127-79-7) was performed in Daphnia magna for 48 hrs at concentration range from 241-323 mg/l. The test was performed in static fresh water system using < 24 hrs daphnia magna. The hardness and temperature of the experiment was kept at 193 mg/L CaCO3 and 20 degree C. After 48 hrs, the EC 50 value for 4-amino-N-(4-methylpyrimidin-2-yl)benzene sulfonamide(127-79-7) was determined to be 277 mg/l.

From same reference (Ecotox database, 2017) for another read across ammonium 3-amino-2,5-dichlorobenzoate(1076-46-6), short term toxicity to aquatic invertebrates was performed in Daphnia magna for 48 hrs. The test was performed in static fresh water system using < 24 hrs daphnia magna. After 48 hrs, the EC 50 value for ammonium 3-amino-2,5-dichlorobenzoate(1076-46-6) was determined to be >1000 mg/l.

Based on the all the weight of evidences, it was considered that 1-(3-aminophenyl)urea (25711-72-2) was likely to be non-toxic to aquatic organism and can be considered to be not classified for short term toxicity to aquatic invertebrates as per the CLP regulations.

Toxicity to algae and cyanobacteria

Toxicity to algae and cyanobacteria for 1-(3-aminophenyl)urea (25711-72-2) was summarised with predicted data for target and by using functional read across studies as follows:

Using the OECD QSAR toolbox version 3.3 with log kow as the primary descriptor and considering the five closest read across substances, the short term toxicity on aquatic algae and cyanobacteria was predicted for target substance 1-(3-aminophenyl)urea (25711-72-2). EC50 value was estimated to be 103.62 mg/l for Pseudokirchneriella subcapitata for 72 h duration.

In another prediction done using the EPI Suite ECOSAR version 1.10, the short term toxicity on green algae was predicted for test substance 1-(3-aminophenyl)urea  (CAS:25711-72-2). On the basis of effects observed in a static freshwater system, the effect concentration EC50 value for the substance is estimated to be 4277.416 mg/l for Species for 96 hrs duration.

Toxicity to algae test was performed in read across 3 Aminophenol from J-check database (2017). After 72 hrs the EC 50 and NOEC value for 3-aminophenol was determined. The EC 50 value and NOEC value for 3 Aminophenol for algae was determined to be 160 and 25 mg/l on the basis of growth rate and 62 and 25 mg/l on the basis of biomass. Thus, based on the value of EC50 for growth rate, the 3 aminophenol was likely to be non-toxic to algae and can be considered to be not classified as per the CLP regulations.

Based on the all the weight of evidences, it was considered that 1-(3-aminophenyl)urea (25711-72-2) was likely to be non-toxic to aquatic organism and can be considered to be not classified for short term toxicity to aquatic algae as per the CLP regulations.