Registration Dossier
Registration Dossier
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EC number: 903-816-3 | CAS number: -
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Studies were published pre-testing guideline and pre-GLP regulations with limited technical detail.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 944
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 948
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Six albino rabbits were used per dose, up to 20 mL/Kg bw , 24 hr exposure considered occlusive under a rubber cuff and the post exposure observation period was believed to be 14 days.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 3-chloropropene
- EC Number:
- 203-457-6
- EC Name:
- 3-chloropropene
- Cas Number:
- 107-05-1
- Molecular formula:
- C3H5Cl
- IUPAC Name:
- 3-chloroprop-1-ene
- Details on test material:
- As per the IUCLID5 Sections 1.1. - 1.4. for 3-chloropropene.
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- not specified
- Details on dermal exposure:
- Exposure was occlusive for approximately 24 hr.
- Duration of exposure:
- 24 hr
- Doses:
- No data
- No. of animals per sex per dose:
- 6
- Control animals:
- not specified
- Details on study design:
- No data
- Statistics:
- No data
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 2 070 mg/kg bw
- Based on:
- act. ingr.
- Mortality:
- No detailed data
- Clinical signs:
- other: No data
- Gross pathology:
- No data
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: other: EU DSD
- Conclusions:
- The rabbit acute dermal LD50 for 3-chloropropene was 2070 mg/Kg of body weight.
- Executive summary:
When tested for acute dermal toxicity in a manner similar to the existing testing guidelines the structural analog 3 -chloropropene was reported to have an LD50 of 2070 mg/Kg of body weight. Classification and Labeling of 3 -chloropropene is not justified by this finding. This LD50 value is believed to be representative of AC Light Ends.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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