Registration Dossier
Registration Dossier
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EC number: 419-560-6 | CAS number: 4369-14-6
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted according to standard OECD method and under GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 016
- Report date:
- 2016
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- yes
- Test type:
- fixed dose procedure
- Limit test:
- no
Test material
- Reference substance name:
- -
- EC Number:
- 419-560-6
- EC Name:
- -
- Cas Number:
- 4369-14-6
- Molecular formula:
- C9H18O5Si
- IUPAC Name:
- 3-(trimethoxysilyl)propyl prop-2-enoate
- Test material form:
- not specified
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Crj: CD(SD)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- olive oil
- Doses:
- Preliminary sighting study: 200; 500; 100; 20 mg/kg bw
Main study: 2000; 100 mg/kgbw - No. of animals per sex per dose:
- Preliminary sighting study: 3 (male)
Preliminary sighting study: 3 (female)
Main study: 5 (male)
Main study: 5 (female) - Control animals:
- no
- Details on study design:
- no data
Results and discussion
- Preliminary study:
- 2000 mg/kg bw: no mortality, no evident toxicity
500 mg/kg bw: no mortality, no evident toxicity
100 mg/kg bw: no mortality, no evident toxicity
20 mg/kg bw: no mortality, no evident toxicity
No animal were found dead
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- One female rat of the 2000 mg/kg bw died
- Clinical signs:
- Decreased spontaneous locomotion, decreased respiration rate, ptosis, salivation and mucous stool were observed in 1000 and 2000 mg/kg bw of both sexes
- Gross pathology:
- reddish spots of mucosa in glandular stomach was observed in the dead female rat. Adhesion to diphragm and liver in the forestomach was observed in a rat of 2000 mg/kg bw group
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- According to the results of the acute oral toxicty test acryloxypropyltrimethoxysilane, LD50 > 2000 mg/kg bw no classification is required
- Executive summary:
The acute oral toxicty of acryloxypropyltrimethoxysilane is above 2000 mg/kg bw
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