Registration Dossier
Registration Dossier
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EC number: 266-841-2 | CAS number: 67662-96-8
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
Based on geometric mean measured test concentrations, the 72-hour EyC50 and the 0-72 hour EbC50 and ErC50 values were calculated to be 3.8, 3.7 and 6.0 mg/L, respectively. The corresponding 72-hour EyC10 and the 0-72 hour EbC10 and ErC10 values were 0.61, 0.41 and 3.1 mg/L.
The corresponding NOEC values for yield, biomass and specific growth rate after 72 hours were 0.41, 0.41 and 3.0 mg/L, respectively.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 6 mg/L
- EC10 or NOEC for freshwater algae:
- 3.1 mg/L
Additional information
The preferred observational end point in this study is algal growth rate inhibition because it is not dependent on the test design (ECHA guidance Chapter R.7b v1.1). The EU CLP regulation (No 1272/2008 and its adaption 286/2011) also states that classification should be based on the ErC50. The preferred observational endpoint in long-term studies is the EC10 value because it is derived from the dose response curve. In contrast the NOEC depends on the experiment design (e.g. the concentrations used in the test). Thus the 72-h EC50 and EC10 based on growth rate are used for classification purposes.
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