Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 942-705-4 | CAS number: 2151868-08-3
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
An increase in cell proliferation of draining lymph nodes, statistically significant at the highest concentration, was observed in all dose groups, with a Stimulation Index of 2.21, 1.84 and 2.87 at the low, medium and high dose (2.5 %, 5 % and 10 %), respectively.
The lack of dose-relation was ascribed to inhomogeneous values of absorbance within Group 3. An abnormally high value for animal no. 41 of Group 4 (Replicate 1) was also observed. Nevertheless, values of SI were above the threshold of 1.6 for all treated groups.
In the group treated with the positive control item, a Stimulation Index of 9.30 was calculated. As it was greater than 2, the study was regarded as valid.
Migrated from Short description of key information:
The potential of the test item, V516690, to cause skin sensitisation reactions following topical application to the skin of CBA/JN (CBA/J) mice, was assessed using the LLNA:BrdU-ELISA method, according to the OECD Guideline for testing of chemicals no. 442b. An increase in cell proliferation of draining lymph nodes was observed in all treatment groups. The calculated Stimulation Indices were 2.21, 1.84 and 2.87 at low, mid- and high dose levels, respectively.
Justification for classification or non-classification
European legislation concerning the classification, packaging and labelling of dangerous substances (Council Regulation (EC) No. 1272/2008 and subsequent revisions) would indicate the following:
Classification : Category 1 ;
Signal word: Warning ;
Hazard statement: H317: May cause an allergic skin reaction
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
