Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 210-478-4 | CAS number: 616-38-6
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: peer-reviewed data
Data source
Referenceopen allclose all
- Reference Type:
- other: database
- Title:
- Dimethyl Carbonate [CAS 616-38-6, HSDB number 6928]
- Author:
- HSDB (Hazardous Substances Database), U.S. National Library of Medicine
- Year:
- 2 003
- Bibliographic source:
- http://toxnet.nlm.nih.gov/cgi-bin/sis/search/f?./temp/~3O9KQg:1
- Reference Type:
- review article or handbook
- Title:
- Chemical risk analysis: a practical handbook 2004 [Elsevier Ltd.]
- Author:
- Bernard Martel, Keith Cassidy
- Year:
- 2 004
- Bibliographic source:
- Chemical risk analysis: a practical handbook 2004; Elsevier Ltd; page 442
- Reference Type:
- publication
- Title:
- no data
- Author:
- unknown
- Year:
- 1 979
- Bibliographic source:
- FCTXAV Food and Cosmetics Toxicology, London, UK V.1-19, 1963-81; for publisher information, see : FCTOD7 Food and Chemical Toxicology, Volume 17, page 361, 1979
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: no data
- Deviations:
- not specified
- GLP compliance:
- not specified
- Test type:
- other: no data
Test material
- Reference substance name:
- Dimethyl carbonate
- EC Number:
- 210-478-4
- EC Name:
- Dimethyl carbonate
- Cas Number:
- 616-38-6
- Molecular formula:
- C3H6O3
- IUPAC Name:
- dimethyl carbonate
Constituent 1
Test animals
- Species:
- other: mouse and rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Doses:
- no data
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
Results and discussion
Effect levelsopen allclose all
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 6 000 mg/kg bw
- Based on:
- not specified
- Remarks on result:
- other: LD50(mouse)
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 13 000 mg/kg bw
- Based on:
- not specified
- Remarks on result:
- other: LD50(rat)
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- - LD50 in the rat: 13 g/kg bw
- LD50 in the mouse: 6 g/kg bw
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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