Registration Dossier
Registration Dossier
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EC number: 226-643-9 | CAS number: 5445-19-2
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Performed using OECD Guidelines for Testing of Chemicals No. 402 "Acute Dermal Toxicity" Method B3
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 000
- Report date:
- 2000
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Methyl 2-bromohexanoate
- EC Number:
- 226-643-9
- EC Name:
- Methyl 2-bromohexanoate
- Cas Number:
- 5445-19-2
- Molecular formula:
- C7H13BrO2
- IUPAC Name:
- methyl 2-bromohexanoate
- Test material form:
- other: Liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River (UK) Ltd.
- Age at study initiation: 8 - 12 weeks
- Weight at study initiation: 211 - 235 g (Female), 203 - 225 g (Male)
- Housing: Solid-floor polypropylene cages
- Diet (e.g. ad libitum): Free access
- Water (e.g. ad libitum): Free access
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19 - 25°C
- Humidity (%): 30 - 70%
- Air changes (per hr): 15
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: back and flanks
- % coverage: 10%
- Type of wrap if used: Surgical gauze
REMOVAL OF TEST SUBSTANCE
- Washing (if done): cotton wool moistened with distilled water
- Time after start of exposure: 24 Hr
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 1.57 ml/Kg
- Concentration (if solution): neat
- Constant volume or concentration used: yes - Duration of exposure:
- 24 Hours
- Doses:
- 1.57 ml/Kg
- No. of animals per sex per dose:
- 5
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: 0.5, 1, 2 and 4 Hrs and subsequently once daily. Weighing - weekly
- Necropsy of survivors performed: yes
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
Applicant's summary and conclusion
- Interpretation of results:
- relatively harmless
- Remarks:
- Migrated information > 2000 mg/Kg Criteria used for interpretation of results: EU
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