Registration Dossier
Registration Dossier
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EC number: 211-617-1 | CAS number: 674-82-8
Endpoint summary
Administrative data
Description of key information
Skin irritation: 2 supporting studies available: moderately irritating (limited data only)
Eye irritation: 1 supporting study available: irritating (limited data only)
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
There is only very restricted information available which can give a hint on the skin irritancy potential of Diketene. The substance was tested for its skin irritant properties in rabbits and both publications confirm skin irritation.
The information on eye irritancy properties of Diketene is also not reliable. Diketene was tested for its eye irritant properties in rabbits and irreversible effects on conjunctivae and iris were observed in the animals after application.
Effects on skin irritation/corrosion: irritating
Effects on eye irritation: irritating
Justification for classification or non-classification
Only a limited amount of invalid data which might give a hint on the skin and eye irritation properties of Diketene is available. However, for precautionary reasons Diketene is be classified as irritant to the skin (XI; R37/38 - irritating to respiratory system/skin; STOT SE 3; H335 - may cause respiratory irritation; Skin Irrit. 2; H315 - causes skin irritation) and eye (Xi; R41 - risk of serious damage to eyes; Eye Dam.1; H318 - causes serious eye damage) according to the criteria laid down in the EU Dangerous Substances Directive (67/548/EEC) and in the EU Classification Labelling and Packaging Regulation (1272/2008/EC).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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