Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 700-291-0 | CAS number: 1000701-92-7
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: only secondary literature
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Acute 9-day and 13-week inhalation studies of ethylene glycol monohexylether
- Author:
- Klonne, DR et al.
- Year:
- 1 987
- Bibliographic source:
- Fundam. Appl. Toxicol. 8: 198-206
- Reference Type:
- publication
- Title:
- No information
- Author:
- Klonne, DR et al.
- Year:
- 1 986
- Bibliographic source:
- The Toxicologist 6 (1), 60, Abstract No. 237
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 2 005
Materials and methods
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Hexylglycol (EGHE)
- IUPAC Name:
- Hexylglycol (EGHE)
- Reference substance name:
- 2-hexyloxyethanol
- EC Number:
- 203-951-1
- EC Name:
- 2-hexyloxyethanol
- Cas Number:
- 112-25-4
- Molecular formula:
- C8H18O2
- IUPAC Name:
- 2-(hexyloxy)ethanol
Constituent 1
Constituent 2
Test animals
- Species:
- rat
Administration / exposure
- Route of administration:
- inhalation
- Duration of exposure:
- 4 h
- Concentrations:
- 83 ppm
Results and discussion
Effect levels
- Dose descriptor:
- LC50
- Effect level:
- > 0.5 mg/L air
- Exp. duration:
- 4 h
Applicant's summary and conclusion
- Executive summary:
Hexylglycol is the parent compound and occurs together with the sodium salt of the submission substance identity. For systemic toxicity, the glycol ether is regarded as a worst case as it is a good solvent and most probably taken up in higher percentages than the ionic salt.
Testing of this specific endpoint is additionally advised against for the submission substance because of its corrosive properties.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
