Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 607-233-2 | CAS number: 2343-89-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 13/7/15 to 31/7/15
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Recently conducted study performed to OECD guideline and under GLP
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.1 (Acute Toxicity for Fish)
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Details on sampling:
- - Sampling method: Fresh test media (0 & 72h) from bulk preparation, old test media (24 & 96h)
- Sample storage conditions before analysis: analysed on day of receipt - Vehicle:
- no
- Test organisms (species):
- Oncorhynchus mykiss (previous name: Salmo gairdneri)
- Details on test organisms:
- TEST ORGANISM
- Common name: Rainbow trout
- Strain: No data
- Source: Brow Well Fisheries Ltd, Skipton, Yorkshire, UK
- Age at study initiation (mean and range, SD): No data
- Length at study initiation (length definition, mean, range and SD): 4.9 cm (SD 0.2 cm)
- Weight at study initiation (mean and range, SD): 1.58g (SD 0.27g)
- Method of breeding: No data
- Feeding during test: Not fed
ACCLIMATION
- Acclimation period: 7d
- Acclimation conditions (same as test or not): No data
- Type and amount of food: Commerical trout pellets
- Feeding frequency: No data
- Health during acclimation (any mortality observed): None - Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Hardness:
- No data
- Test temperature:
- 14 - 15oC
- pH:
- 7.3 - 7.8
- Dissolved oxygen:
- 5.4 - 9.2mg/L
Minimum DO recorded 5.4 mg/L (52% ASV) in control 'old' test media - Salinity:
- No data
- Nominal and measured concentrations:
- Nominal concentrations (mg/L): 0 (control), 2.2, 4.5, 10, 22 45; Analytical concentrations (mg/L): 0 (control), 2.2, 4.2, 8.8, 20, 38 (mean fresh media concn
- Details on test conditions:
- TEST SYSTEM
- Test vessel:
- Type (delete if not applicable): closed
- Material, size, headspace, fill volume: glass, 20 L, no headspace, 20 L
- Aeration: None
- No. of organisms per vessel: 7
- No. of vessels per concentration (replicates): 1
- No. of vessels per control (replicates): 1
- No. of vessels per vehicle control (replicates): 1
- Biomass loading rate:
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water:
- Total organic carbon:
- Particulate matter:
- Metals:
- Pesticides:
- Chlorine:
- Alkalinity:
- Ca/mg ratio:
- Conductivity:
- Culture medium different from test medium:
- Intervals of water quality measurement:
OTHER TEST CONDITIONS
- Adjustment of pH:
- Photoperiod:
- Light intensity:
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) :
TEST CONCENTRATIONS
- Spacing factor for test concentrations:
- Justification for using less concentrations than requested by guideline:
- Range finding study
- Test concentrations:
- Results used to determine the conditions for the definitive study:
TEST SYSTEM
- Test vessel: 20L glass
- Type: closed
- Material, size, headspace, fill volume: Glass, 20L, no headspace, 20L fill volume, sealed
- Aeration: None
- No. of organisms per vessel: 7
- No. of vessels per concentration (replicates): 1 (no replicates)
- No. of vessels per control (replicates): 1 (no replicates)
- Biomass loading rate: 0.55g/L
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Dechlorinated tap water
- Total organic carbon: No data
- Particulate matter: No data
- Metals: No data
- Pesticides: No data
- Chlorine: No data
- Alkalinity: No data
- Ca/mg ratio: No data
- Conductivity: No data
- Intervals of water quality measurement: No data
OTHER TEST CONDITIONS
- Adjustment of pH: None
- Photoperiod: 16:8 Light:Dark
- Light intensity: No data
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) :
TEST CONCENTRATIONS
- Spacing factor for test concentrations: x2
- Results used to determine the conditions for the definitive study: OECD 201 72h Algae; OECD 202 48h Daphnia magna - Reference substance (positive control):
- no
- Duration:
- 24 h
- Dose descriptor:
- LC50
- Effect conc.:
- 13 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: 95% CI (10-17)
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- 6.1 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: -
- Duration:
- 72 h
- Dose descriptor:
- LC50
- Effect conc.:
- 6.1 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: -
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 6.1 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: -
- Details on results:
- - Behavioural abnormalities: None
- Observations on body length and weight: no data
- Other biological observations: None observed
- Mortality of control: None
- Other adverse effects control: None
- Abnormal responses: None
- Any observations (e.g. precipitation) that might cause a difference between measured and nominal values: None
- Effect concentrations exceeding solubility of substance in test medium: None - Sublethal observations / clinical signs:
Results based on average measured 'new' concentrations (mg/L)
Time
(h)
LC50
(mg/L)
95% CI
NOEC
(mg/L)
LOEC
(mg/L)
24
13
10 - 17
8.8
20
48
6.1
-
4.2
8.8
72
6.1
-
4.2
8.8
96
6.1
-
4.2
8.8
- Validity criteria fulfilled:
- no
- Remarks:
- DO <60% ASV in some 'old' test media
- Conclusions:
- The 96 hour LC50 value of the test substance was determined to be 6.1 mg/L, under semi-static condicitons. Results based on average measured 'new' concentrations.
- Executive summary:
The 96–hour-acute toxicity of 2-propenoic acid to rainbow trout (Oncorhynchus mykiss) was studied under semi-static conditions. The study was conducted in accordance with EU method C.2 and OECD guideline 202, in compliance with GLP.
Fish were exposed to a control and nominal test concentrations of 2.5, 4.5, 10, 22 and 45mg/L for 96 hours.
Analytical measurements at 0 and 72 hour 'new' test solutions ranged from 74 – 105% of nominal. Analytical measurements at 24 and 96 hour old test solutions ranged from 76 – 96% of nominal. Dissolved oxygen % ASV <60% in some 'old' test solutions but this is not considered to have affected the test result and the test is considered valid.
The results are expressed in terms of mean measured 'new' test concentrations. Observations for mortality and sub-lethal effects were made daily. The 96–hour LC50 value was 6.1 mg/L (not possible to calculate 95% CI). The 96–hour NOEC based on mortality was 4.2 mg/L. There were no sub-lethal effects observed.
This study is classified as acceptable and satisfies the guideline requirements for an acute toxicity study with freshwater fish.
Results Synopsis
Test Organism: Rainbow trout (Oncorhynchus mykiss), mean weight 1.58g, mean length 4.9 cm
Test Type: Semi-static, sealed vessels, no aeration
LC50: 6.1 mg/L (95% C.I. could not be calculated)
NOEC: 42 mg/L
LOEC 8.8 mg/L
Reference
Description of key information
The Key Study reported a 96 hour LC50 value for the toxicity of 2 -propenoic acid, 2 -fluoro, methyl ester to the freshwater fish Oncorhynchus mykiss of 6.1 mg/L, under semi-static conditions. The results were based on average measured concentrations (Sacker, 2015).
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 6.1 mg/L
Additional information
The 96-hour LC50 for 2-propenoic acid, 2-fluoro, methyl ester in rainbow trout (Oncorhynchus mykiss) was 6.1 mg/l under semi-static conditions in sealed vessels with no aeration. No mortality was observed at measured concentrations of 2.2 and 4.2 mg/L. No symptoms of toxicity (sub-lethal effects) were observed.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.