2-[(2-[2-(dimethylamino)ethoxy]ethyl)methylamino]ethanol

Water solubility

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

weight of evidence

Study period:

2003-05-27

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Qualifier:

no guideline followed

Principles of method if other than guideline:

Deionized water and sample were placed in five 4 ml vials at 5 concentrations and single phase observations were made.

GLP compliance:

yes (incl. QA statement)

Remarks:

Report represents data generated in the “spirit of” Good Laboratory Practice. GLP deviations were that a Study Plan was not written, however Study-Specific Supplements were provided to study personnel describing laboratory work in detail.

Type of method:

other: single phase observations

Specific details on test material used for the study:

- Name of test material (as cited in study report): Jeffcat ZF-10, 2-((2-(2-(dimethylamino)ethoxy)ethyl)methyl-amino)-ethanol
- Substance type: Amine
- Physical state: Clear colourless liquid
- Analytical purity: 99%
- Lot/batch No.: 324756
- Storage condition of test material: 22 °C in the dark

Key result

Water solubility:

> 570 g/L

Temp.:

24 °C

pH:

ca. 12.55

Conclusions:

The water solubility of the test substance was determined to be greater than 570 g/L at 24°C.

Reference 2

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

weight of evidence

Study period:

1990-05-14

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

GLP compliance:

yes (incl. QA statement)

Type of method:

other: Mixtures containing from 5.4 - 94.6% w/w test substance in distilled water at 20°C were prepared.

Specific details on test material used for the study:

- Name of test material (as cited in study report): Texacat ZF-10, 2-[[2-[2-(dimethylamino)ethoxy]ethyl]methylamino]ethanol
- Physical state: Clear colorless liquid
- Analytical purity: 97%
- Lot/batch No.:90/329
- Experiation date of the lot/batch: Approximately two years from receipt (received on 30 MArch 1990)
- Storage condition of test material: Dark at room temperature

Key result

Temp.:

20 °C

Remarks on result:

completely miscible

Details on results:

The substance was found to be miscible in all proportions with distilled water at 20°C.

The substance was found to be miscible in all proportions (5.4 to 94.6 % w/w) at 20°C.

Conclusions:

The substance was found to be miscible in all proportions at 20°C.

Description of key information

The water solubility of the test substance was determined to be >570 g/L at 24°C and completely miscible in water based on two studies in a weight of evidence approach.

BC Research Inc. (2003) determined a water solubility of >570 mg/L at 24°C and pH 12.55 by single phase observations. The study was considered to be reliable with restrictions (Klimisch 2).

In a second study the test substance was found to be miscible in all portions at 20°C according to the EC method A.6, performed by Huntingdon Research Centre Ltd. (1990) and considered reliable without restrictions (Klimisch 1).

Additional information

The substance is completely miscible in water. A water solubility value of >570 g/L at 24 °C is reported.