Registration Dossier
Registration Dossier
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EC number: 231-555-9 | CAS number: 7632-00-0
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: secondary source
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 1 985
Materials and methods
- Principles of method if other than guideline:
- Method: other
- GLP compliance:
- yes
- Remarks:
- according to SIDS
Test material
- Reference substance name:
- Sodium nitrite
- EC Number:
- 231-555-9
- EC Name:
- Sodium nitrite
- Cas Number:
- 7632-00-0
- Molecular formula:
- HNO2.Na
- IUPAC Name:
- sodium nitrate
- Details on test material:
- sodium nitrite
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- nose only
- Vehicle:
- other:
- Duration of exposure:
- 4 h
- Concentrations:
- 10 and 100 mg/m3
- No. of animals per sex per dose:
- 10
- Details on study design:
- Aerosols dried rapidly so animals were exposed to dry particulate test material. Air humidity was approximately 60%. Mass mean aerodynamic diameter was 1.7 and 2.0 ìm for the low and high groups, respectively. Controls killed after exposure and blood taken for measurement of methaemoglobin, the remaining animals were maintained for 14 days, and then subject to a full post-mortem examination.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC0
- Effect level:
- 0.095 mg/L air
- Exp. duration:
- 4 h
- Clinical signs:
- other: During exposure signs typically seen in restrained animals were somewhat more severe in treated animals. Methaemoglobin was significantly increased above concurrent control values only in females exposed to 10 mg/m3. However, the increase was judged to be
Applicant's summary and conclusion
- Conclusions:
- Current controls of exposure of workers to sodium nitrite
(i.e. at 10 mg/m3) was more than adequately protective for
acute hazards.
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