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EC number: 500-114-5 | CAS number: 52408-84-1 1 - 6.5 moles propoxylated
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: dermal
Administrative data
- Endpoint:
- short-term repeated dose toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- April 25, 1983 - June 01, 1984
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 1984
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- C-486 (500 mg/kg bw) was applied to the backs of New Zealand White albino rabbits (5/sex/dose) once daily, 5 days/week for 2 weeks. Six animals per group were sacrificed after 15 days and remaining 4 animals after 30 days. Animals were monitored for the clinical signs and mortality, body weight gains, dermal reactions, gross pathology and histopathology.
- GLP compliance:
- no
- Limit test:
- yes
Test material
- Reference substance name:
- Glycerol, propoxylated, esters with acrylic acid
- EC Number:
- 500-114-5
- EC Name:
- Glycerol, propoxylated, esters with acrylic acid
- Cas Number:
- 52408-84-1
- Molecular formula:
- (C3H6O)m(C3H6O)n(C3H6O)oC12H14O6
- IUPAC Name:
- Poly[oxy(methyl-1,2-ethanediyl)], .alpha.,.alpha.',.alpha.''-1,2,3- propanetriyltris[.omega.-[(1-oxo-2-propenyl)oxy]]-
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Hazleton-Dutchland Inc., Denver, Pennsylvania
- Age at study initiation: Young adults
- Weight at study initiation: Males: 2.1-2.3 kg; Females: 2.2-2.7 kg
- Housing: Individually housed in a suspended, stainless steel cages
- Diet: Purina rabbit chow, ad libitum
- Water: ad libitum
- Acclimation period: 14 days
ENVIRONMENTAL CONDITIONS
- Temperature: 60- 70 °F
- Photoperiod: 12 h light/ 12 h dark
Administration / exposure
- Type of coverage:
- open
- Vehicle:
- corn oil
- Details on exposure:
- TEST SITE
- Area of exposure: Back of the animal, 10 % of the total body surface area
- Time intervals for shavings or clipplings: Reclipped as necessary during the study
REMOVAL OF TEST SUBSTANCE
- Site was wiped with dry gauze on the day following each dose, after dermal observations
TEST MATERIAL
- Amount(s) applied: 500 mg/kg bw/d (2.0 mL/kg/d)
- Concentration: 25 % w/v in vehicle
- Constant volume or concentration used: Yes
VEHICLE
- Amount(s) applied (volume or weight with unit): 2 mL/kg/d (corn oil)
USE OF RESTRAINERS FOR PREVENTING INGESTION: Yes - Analytical verification of doses or concentrations:
- no
- Duration of treatment / exposure:
- 14 days
- Frequency of treatment:
- Daily, 5 days/week for 2 weeks
Doses / concentrations
- Dose / conc.:
- 500 mg/kg bw/day (nominal)
- No. of animals per sex per dose:
- five
- Control animals:
- yes, concurrent vehicle
- Details on study design:
- - Rationale for animal assignment: Randomly assigned using random number table
- Positive control:
- No
Examinations
- Observations and examinations performed and frequency:
- CAGE SIDE OBSERVATIONS: Yes
- Time schedule: Daily
DETAILED CLINICAL OBSERVATIONS: Yes
- Time schedule: Daily
DERMAL IRRITATION: Yes
- Time schedule for examinations: Daily
BODY WEIGHT: Yes
- Time schedule for examinations: Pretest and weekly during the study - Sacrifice and pathology:
- GROSS PATHOLOGY: Yes
HISTOPATHOLOGY: Yes - Other examinations:
- None
- Statistics:
- Variance of the two groups were tested for equality using F-test followed by t-test (if variances were equal) or Welch's test (if variances differed)
Results and discussion
Results of examinations
- Clinical signs:
- effects observed, treatment-related
- Description (incidence and severity):
- Nasal discharge, ocular irritation, fecal or urinary staining, necrosis and bruising of the ears, necrosis on the neck, necrosis and swelling of the scrotum, respiratory rate irregularities, hypoactivity and hyperthermia of the ears.
- Dermal irritation:
- effects observed, treatment-related
- Description (incidence and severity):
- Dermal effects included moderate to severe erythema and edema, necrosis, eschar formation with subsequent exfoliation, ataxia, desquamation and fissuring.
- Mortality:
- mortality observed, treatment-related
- Description (incidence):
- One female was found dead on Day 12
- Body weight and weight changes:
- effects observed, treatment-related
- Description (incidence and severity):
- - Body weight gain in animals in treatment group was lower than control group throughout the dosing period
- Animals gained weight in recovery period - Food consumption and compound intake (if feeding study):
- not examined
- Food efficiency:
- not examined
- Water consumption and compound intake (if drinking water study):
- not examined
- Ophthalmological findings:
- not examined
- Haematological findings:
- not examined
- Clinical biochemistry findings:
- not examined
- Urinalysis findings:
- not examined
- Behaviour (functional findings):
- not examined
- Organ weight findings including organ / body weight ratios:
- not examined
- Gross pathological findings:
- effects observed, treatment-related
- Description (incidence and severity):
- Presence of dermal lesions like desquamation, eschar, scabs and/or sores and exfoliations
- Histopathological findings: non-neoplastic:
- effects observed, treatment-related
- Description (incidence and severity):
- Observations in female animal which was found dead on Day 12:
- Slight to moderate acute fibrinopurulent pericarditis, some purulent inflammation in both kidneys and a slight chronic meningitis with few scattered small granulomas in the cerebrum and extensive dermal necrosis at the application site associated with an acute inflammatory reaction
Observations in animals sacrificed after 2 weeks:
- Fairly extensive dermal necrosis accompanied by an acute purulent inflammatory response.
Observations in animals sacrificed after 4 weeks:
- Inflammation with a conspicuous increase in the amount of dense fibrocollagenous tissue; minimal to mild inflammatory process in the epicardium and/ or pericardium (in 3 females). - Histopathological findings: neoplastic:
- not examined
Effect levels
- Dose descriptor:
- LOAEL
- Effect level:
- 500 mg/kg bw/day (nominal)
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- body weight and weight gain
- clinical signs
- Remarks on result:
- other: effects likely secondary to local irritation
Target system / organ toxicity
- Critical effects observed:
- no
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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