Castor oil, dehydrated

Bioaccumulation: aquatic / sediment

Administrative data

Endpoint:

bioaccumulation: aquatic / sediment

Type of information:

calculation (if not (Q)SAR)

Remarks:

Migrated phrase: estimated by calculation

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Data estimated by BCFBAF v.3.01 which uses a valid calculation method; the test substance was found to fall in the applicability domain of this method and results were adequate for the purpose of classification and labelling and/or risk assessment.

Data source

Reference

Reference Type:

other: Software

Title:

BCFBAF v.3.01 (EPIWEB v.4.1)

Author:

U.S. Environmental Protection Agency

Year:

2012

Bibliographic source:

US EPA. Estimation Programs Interface Suite™ for Microsoft® Windows, v 4.10. United States Environmental Protection Agency, Washington, DC, USA.

Materials and methods

Test guideline

Guideline:

other: REACH guidance on QSARs: Chapter R.6. QSARs and grouping of chemicals

Principles of method if other than guideline:

The BCF value was calculated using BCFBAF v.3.01 program of EPIWEB v.4.1. Experimental log Kow was used for the calculation.

Test material

Test material information

Constituent 1

Reference substance name:

C18:0 triglyceride

IUPAC Name:

C18:0 triglyceride

Constituent 2

Reference substance name:

adduct formed by two C18:3 triglycerides

IUPAC Name:

adduct formed by two C18:3 triglycerides

Results and discussion

Any other information on results incl. tables

The estimated BCF values for C18:0 triglyceride and for an adduct formed by two C18:3 triglycerides using BCFBAF v.3.01 (EPIWEB v.4.1) were found to be 3.162 L/kg wet-wt (log BCF was 0.5).

Applicant's summary and conclusion

Conclusions:

The estimated BCF values for C18:0 triglyceride and for an adduct formed by two C18:3 triglycerides using BCFBAF v.3.01 (EPIWEB v.4.1) were found to be 3.162 L/kg wet-wt (log BCF was 0.5).

Executive summary:

The bioaccumulation potential (BCF) of castor oil, dehydrated was estimated according to the BCFBAF v.3.01 model of EPIWEB v.4.1 considering a range of components present in the substance, i.e. from a C18:0 triglyceride to an adduct formed by two C18:3 triglycerides. The BCF was equivalent to 3.162 L/kg wet weight in all cases, which corresponds to a low bioaccumulation potential.

Based on its physical form (solid), low water solubility and high adsorption coefficient, the substnace is unlikely to be significantly bioavailable to aquatic organisms. When ingested, the constituent triglycerides are well known to be broken down into glycerol and fatty acids which then undergo β-oxidation and are used as a source of energy (Oxley, 2005 and 2006). As such, castor oil, dehydrated is not expected to bioaccumulate in aquatic organisms.