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EC number: 236-671-3 | CAS number: 13463-41-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
The information contained within this robust summary document comes from studies which are in the ownership of Arch Chemicals Inc. and which are protected in several regions globally. This information may not be used for any purpose other than in support of the Chemical safety Report submitted by Arch Chemicals Inc. under RegulationEC 1907/2006.
Skin Irritation
In a GLP compliant acute dermal irritation / corrosion test in rabbits according to OECD 404 conducted byWolf (2001), no irritation was observed.
In a further GLP compliant study byCerven (1991), which complies with OECD 404, some slight Oedema was noted.
Accordingly, zinc pyrithione does not meet the criteria for classification as irritating to skin and is thus classified as non-irritating to skin for both DSD and CLP.
Table 5.4: Summary of skin irritation
Method |
Results |
Remarks |
Reference |
OECD 404. GLP (self certification by the laboratory) Skin, Rabbit, New Zealand Albino, 6 males. |
Erythema – 0.0 Oedema – 0.0 Reversibility – Yes Not irritating to skin |
Reliability – 1 Purpose flag Study result type The test material was Zinc Pyrion powder (97.9%) |
Key study Wolf T (2001) (unpublished) |
US EPA 81-5, which complies with OECD 404. GLP (self certification by the laboratory) Skin, Rabbit, New Zealand Albino, 6 males |
Erythema – 0.0 Oedema – 0.11 Reversibility – Yes Mildly irritating(below classification level) |
Reliability – 1 Purpose flag Study report type The test material was 0.5g water moistened Zinc Omadine powder (>97%) |
Cerven DR (1991) (unpublished) |
.
Eye Irritation
In a GLP study to OECD 405,Wolf (2002)identified severe and irreversible corneal lesions at 24 hours.
In a further GLP study conducted to US EPA 81-5 which complies with OECD 405, Cerven (1991) also noted severe corneal damage which persisted to day 7 (at which time animals were euthanised).
The above data indicates that zinc pyrithione meets the criteria for classification as:-
DSD: Irritant, R41, Risk of serious damage to eyes.
CLP: Eye Dam cat 1, H318, Causes serious eye damage.
Table 5.5: Summary of eye irritation
Method |
Results |
Remarks |
Reference |
US EPA 81-5, which complies with OECD 404. GLP (self certification by the laboratory) Eye, Rabbit, New Zealand Albino, 8 females and 1 male.
|
Cornea– Unwashed eye: 3.1 Washed eye: 3.6 Iris– Unwashed eye: 1.2 Washed eye: 1.0 Conjunctiva Redness– Unwashed eye: 3.0 Washed eye: 3.0 Chemosis– Unwashed eye: 4.0 Washed eye: 3.4 Reversibility– Unwashed eye: Due to persistence and severity of irritation, animals were euthanized on day 7. Washed eye: Similar responses were noted, only one eye cleared by day 21, while the response in the other animals persisted.
|
Reliability – 1 Purpose flag Study result type The test material was 0.1 ml Zinc pyrithione powder (>97%). |
Cerven DR (1991) (unpublished) |
OECD 405. GLP (self certification by the laboratory) Eye, Rabbit, New Zealand Albino, 1 female.
|
Cornea– 4 (at 24 hr) Iris– No ophthalmological examination was possible Conjunctiva Redness– 3 (at 24 hr) Chemosis– 4 (at 24 hr) Reversibility– Severe and irreversible corneal lesions (corneal perforation suspected) severe redness and swelling were noted 24 hr p.a. Due to the severity of lesions the animal was euthanized 24 hr p.a.
|
Reliability – 1 Purpose flag Study result type The test material was 0.1 ml Zinc Pyrithione powder (97.9%) |
Key study Wolf T (2001) (unpublished) |
Effects on eye irritation: corrosive
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.