Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-882-9 | CAS number: 75-59-2
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin corrosion: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 2013
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data from database with results from Corrositex tests.
Data source
Reference
- Reference Type:
- other: database
- Title:
- Corrositex database
- Author:
- Invitro International
- Year:
- 2 013
- Bibliographic source:
- Corrositex database, available via http://www.invitrointl.com/store/
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 435 (In Vitro Membrane Barrier Test Method for Skin Corrosion)
- Deviations:
- not specified
- GLP compliance:
- no
Test material
- Reference substance name:
- tetramethylammonium pentahydrate
- IUPAC Name:
- tetramethylammonium pentahydrate
- Reference substance name:
- 10424-65-4
- Cas Number:
- 10424-65-4
- IUPAC Name:
- 10424-65-4
- Test material form:
- other: tetramethylammonium hydroxide pentahydrate
- Details on test material:
- Not specified
Constituent 1
Constituent 2
Results and discussion
In vitro
Results
- Remarks on result:
- positive indication of irritation
Any other information on results incl. tables
According to the Corrositex database TMAOH pentahydrate should be classified in ADR/DOT packing group II for transport, based on experimental test results. Criteria for classification in packing group II correspond with those for skin corrosive 1B.
Applicant's summary and conclusion
- Interpretation of results:
- other: Category 1B (corrosive)
- Remarks:
- according to EC 1272/2008
- Conclusions:
- According to the Corrositex database, TMAOH pentahydrate should be classified as packing group II for transport (ADR/DOT) based on experimental results from Corrositex testing. Based on the fact that the criteria for packing group II are identical to the criteria for the classification as skin corrosive 1B from OECD guideline 435, TMAOH pentahydrate is classified as skin corrosive 1B.
- Executive summary:
According to the Corrositex database, TMAOH pentahydrate should be classified as packing group II for transport (ADR/DOT) based on experimental results from Corrositex testing. Based on the fact that the criteria for packing group II are identical to the criteria for the classification as skin corrosive 1B from OECD guideline 435, TMAOH pentahydrate is classified as skin corrosive 1B.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
