N,N',N'',N'''-tetrakis(4,6-bis(butyl-(N-methyl-2,2,6,6-tetramethylpiperidin-4-yl)amino)triazin-2-yl)-4,7-diazadecane-1,10-diamine

Biodegradation in water and sediment: simulation tests

Administrative data

Endpoint:

biodegradation in water: sediment simulation testing

Type of information:

(Q)SAR

Adequacy of study:

supporting study

Study period:

2022

Reliability:

2 (reliable with restrictions)

Justification for type of information:

Due to the molecular structure of the registered substance and its large molecular size, radiolabeling is technically not feasible and picking a specific carbon atom for radiolabeling in the molecule would not be scientifically justified. Screening tests according to OECD 301 B showed that biodegradation was below 10 % resulting in persistent (P) or very persistent (vP) properties. The substance is insoluble in water < 0.002 g/L (key_Ciba-Geigy_20201.Water solubility.001).
But to address the requested information as good as possible, QSAR estimation was done. OASIS Catalogic v5.12.1 with the model CATALOGIC 301C v.10.14 calculated a biodegradation of 1%. A total of 95 degradation products were identified of which only 13 fulfill the criteria for a more detailed screening according to guidance document R.11 for bioaccumulation, as they have a log Kow of >= 4 paired with a molecular weight of <= 1100 g/mol. After screening those metabolites for the “B/vB” criteria it is assured that none of the above-mentioned degradation product fulfills the PBT/vPvB criteria.

Please see also the attached justification, Iculid chapter 5.2.1"WoE.Structure A Catalogic v5.12.1 BOD 28 days MITI (OECD 301C) v10.14.Biodegradation in water: screening tests" and Iculid chapter 5.3.1 "WoE.QSAR.10 metabolites with potential for bioaccumulation.Catalogic v5.15.2.14.BCF baseline model v.05.12.Bioaccumulation: aquatic / sediment-copy."

Materials and methods

Test material

Test material information

Constituent 1

Reference substance name:

N,N',N'',N'''-tetrakis(4,6-bis(butyl-(N-methyl-2,2,6,6-tetramethylpiperidin-4-yl)amino)triazin-2-yl)-4,7-diazadecane-1,10-diamine

EC Number:

401-990-0

EC Name:

N,N',N'',N'''-tetrakis(4,6-bis(butyl-(N-methyl-2,2,6,6-tetramethylpiperidin-4-yl)amino)triazin-2-yl)-4,7-diazadecane-1,10-diamine

Cas Number:

106990-43-6

Molecular formula:

C132 H250 N32

IUPAC Name:

N2-[2-({4,6-bis[butyl(1,2,2,6,6-pentamethylpiperidin-4-yl)amino]-1,3,5-triazin-2-yl}[3-({4,6-bis[butyl(1,2,2,6,6-pentamethylpiperidin-4-yl)amino]-1,3,5-triazin-2-yl}amino)propyl]amino)ethyl]-N2-[3-({4,6-bis[butyl(1,2,2,6,6-pentamethylpiperidin-4-yl)amino]-1,3,5-triazin-2-yl}amino)propyl]-N4,N6-dibutyl-N4,N6-bis(1,2,2,6,6-pentamethylpiperidin-4-yl)-1,3,5-triazine-2,4,6-triamine

Results and discussion

Transformation products:

yes

Details on transformation products:

Please see table 1 for further information

Any other information on results incl. tables

Table 1: Detailed information on “B/vB” criteria for metabolites fulfilling the criteria for log Kow by Nendza et al. 2006.

Metabolite Number	Quantity [%]	Log Kow	MW [g/mol]	Log BCF 49 d corrected [L/kg wet weight]	Maximal average diameter [nm]	Structural domain [%]	Conclusion
1	2.6	8.3	546	1.75	1.76	88.24	Not B/vB
2	0.2	6.8	562	1.69	1.79	88.57	Not B/vB
3	0.6	8.3	545	2.79	1.73	94.12	Not B/vB
4	0.05	7.8	587	0.85	1.76	86.49	Not B/vB
5	3.1	5.4	617	1.76	1.76	94.87	Not B/vB
9	0.18	7.8	644	0.85	1.96	87.80	Not B/vB
10	8.3	8.3	602	2.33	1.76	94.74	Not B/vB
11	4.9	4.9	603	1.69	1.77	92.11	Not B/vB
12	9.3	9.3	573	1.70	1.74	94.44	Not B/vB
13	4.9	4.9	603	1.48	1.76	94.74	Not B/vB

 

Applicant's summary and conclusion

Conclusions:

The registered substance is not readily biodegradable according to OECD criteria. The calculated degradation products were further evaluated regarding PBT/vPvB criteria. None of the mentabolites fullfilled the respective criteria. Therefore, the risk to the environment both, for the registered substance as well as the degradation products is considered low.