Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 247-118-0 | CAS number: 25584-83-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given (comparable to guidelines/standards). Data were audited by QAU but no reference to GLP standard. Original report not available. Data, reliability and rationale as cited in OECD SIDS (2006).
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
- Reference Type:
- review article or handbook
- Title:
- OECD SIDS Hydroxypropyl acrylate, CAS No. 25584-83-2.
- Author:
- OECD SIDS
- Year:
- 2 006
- Bibliographic source:
- OECD SIDS for SIAM 20, UNEP Publications, October 2006.
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Acrylic acid, monoester with propane-1,2-diol
- EC Number:
- 247-118-0
- EC Name:
- Acrylic acid, monoester with propane-1,2-diol
- Cas Number:
- 25584-83-2
- Molecular formula:
- C6H10O3
- IUPAC Name:
- Reaction mass of 2-hydroxy-1-methylethyl acrylate and 2-hydroxypropyl acrylate
- Details on test material:
- - Name of test material (as cited in study report): Rocryl 430 (Hydroxypropyl acrylate)
- Analytical purity: 97 %
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: CRCD
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 220 - 235 g
- Fasting period before study: yes
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Doses:
- 0, 710, 840, 1000, 1410 and 2000 mg/kg bw
- No. of animals per sex per dose:
- 10 animals/dose (all dose groups except 710 mg/kg bw) and 20 animals/dose (710 mg/kg bw dose group), respectively
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: daily
- Necropsy of survivors performed: yes
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 820 mg/kg bw
- 95% CL:
- 760 - 910
- Mortality:
- For details see Remarks on results including tables and figures.
- Clinical signs:
- other: Signs of toxicity, including passiveness, ataxia and salivation, were observed in several animals.
- Gross pathology:
- No gross lesions were observed in any animal that was sacrificed at the end of the 14-day observation period. The following observations were noted in animals that died during the study: stained muzzle, lungs, stomach and intestines red and fluid-filled, and enlarged stomach.
Any other information on results incl. tables
Mortality:
Dose group [mg/kg bw] |
No. dead / No. dosed |
0 |
0/10 |
710 |
4/20 |
840 |
5/10 |
1000 |
9/10 |
1410 |
10/10 |
2000 |
10/10 |
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.