Registration Dossier
Registration Dossier
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EC number: 263-753-6 | CAS number: 62899-75-6
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study according to EU/OECD guideline.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Cyclohexylethylcarbamoyl chloride
- EC Number:
- 263-753-6
- EC Name:
- Cyclohexylethylcarbamoyl chloride
- Cas Number:
- 62899-75-6
- Molecular formula:
- C9H16ClNO
- IUPAC Name:
- N-cyclohexyl-N-ethylcarbamoyl chloride
- Test material form:
- other: liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Himalayan
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 0.5 ml/patch and animal
- Duration of treatment / exposure:
- 4h
- Observation period:
- 60 minutes, 24, 48 and 72 hours and 4 to 7 days after patch removal
- Number of animals:
- 3 male rabbits
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 1h/24h/48h/72h/4days/5days/6days/7days
- Score:
- 1
- Max. score:
- 1
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 1h/24h/48h/72h/4days/5days/6days/7days
- Score:
- 0
- Max. score:
- 0
Any other information on results incl. tables
Under the present test conditions all three rabbits exposed for 4 hours to 0.5 ml test item/patch and animal (semi-occlusive condition) showed an erythema (grade 1) at the examination time-points 1 hour to 5 days after patch removal, animal no. 1 and 3 until 6 days after patch removal.
There were no systemic intolerance reactions.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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