Isopropyl acetoacetate

Melting point / freezing point

Link to relevant study record(s)

Reference

Endpoint:

melting point/freezing point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

from 2020-04-30 to 2020-05-25

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 102 (Melting point / Melting Range)

Version / remarks:

1995

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.1 (Melting / Freezing Temperature)

Version / remarks:

2008

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

differential scanning calorimetry

Key result

Melting / freezing pt.:

-31.9 °C

Atm. press.:

991.9 hPa

Decomposition:

no

Sublimation:

no

In the temperature range of -50 °C to -10 °C, an endothermic effect (melting) was observed. In the temperature range of 140 °C - 200 °C a second endothermic effect could be detected.

Measurement No.	Sample weight / mg	Onset of Effect / °C	Range of effect / °C	Weight loss / mg	Atmospheric pressure / hPa
PN19622	11.10	-31.40 184.05	-50 to -10 (endo) 140 to 200 (endo)	11.08	991.9
PN19627	10.30	-32.36 184.35	-50 to -10 (endo) 140 to 200 (endo)	10.28	991.8

During the heating phase a distinct endothermic effect was observed in the temperature range of -50 to -10 °C, which can be assigned to the melting of the test item.

As the onset temperatures in both tests do not deviate by more than 0.5 K from their mean value of -31.9 °C, this temperature can be used as melting point.

The test item showed a second endothermic effect in the temperature range of 140 °C - 200 °C, which can be assigned to the boiling of the test item.

No further thermal effects were observed up to the test end temperature of 500 °C.

Conclusions:

The melting point of the test item was determined to be -31.9 °C.

Executive summary:

The melting point of the test item was determined by Differential Scanning Calorimetry according to Regulation (EC) No 440/2008 Method A.1. and OECD Test Guideline 102 (1995). Under ambient conditions, the test item is liquid. The tests were started at ambient temperature. The temperature was first decreased to -90 °C at a constant cooling rate of 0.25 K/min. Afterwards, the temperature was increased up to 500 °C at a constant heating rate of 10 K/min. The measurement was performed under air. During the heating phase a distinct endothermic effect was observed in the temperature range of -50 to -10 °C, which can be assigned to the melting of the test item. As the onset temperatures in both tests do not deviate by more than 0.5 K from their mean value of -31.9 °C, this temperature can be used as melting point.

Description of key information

The melting point of the test item was determined to be -31.9 °C (reference 4.2 -1).

Key value for chemical safety assessment

Melting / freezing point at 101 325 Pa:

-31.9 °C

Additional information

The melting point of the test item was determined by Differential Scanning Calorimetry according to Regulation (EC) No 440/2008 Method A.1. and OECD Test Guideline 102 (1995). Under ambient conditions, the test item is liquid. The tests were started at ambient temperature. The temperature was first decreased to -90 °C at a constant cooling rate of 0.25 K/min. Afterwards, the temperature was increased up to 500 °C at a constant heating rate of 10 K/min. The measurement was performed under air. During the heating phase a distinct endothermic effect was observed in the temperature range of -50 to -10 °C, which can be assigned to the melting of the test item. As the onset temperatures in both tests do not deviate by more than 0.5 K from their mean value of -31.9 °C, this temperature can be used as melting point.