Registration Dossier
Registration Dossier
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EC number: 222-598-4 | CAS number: 3547-33-9
Endpoint summary
Administrative data
Description of key information
The NOEL for systemic toxicity from a 90-day dietary toxicity study on 2-(octylthio)ethanol is 0.4% in the diet, based on decreased terminal body weights, and increased liver and kidney weights.
The NOEL for systemic toxicity from a 21-day dermal toxicity study on 2-(octylthio)ethanol is at least 200 mg/kg. The NOEL for dermal irritation is 50 mg/kg.
Key value for chemical safety assessment
Additional information
In a 90 -day feeding study, male and female Sprague-Dawley rats were fed 2-(octylthio)ethanol in their diet at concentrations of 0, 0.08, 0.4 or 2%. Terminal body weights were reduced in the 2% dietary dose group (males, 8.6%; females, 10%). Food consumption was also slightly reduced in the 2% dietary dose group. In the 2% dose group, terminal liver weights were increased (males, 35%; females, 38%); terminal liver weights relative to body weights were increased (males, 36%; females, 53%); and kidney weights relative to body weights were increased (males, 12%; females, 18%). There were no treatment-related histopathologic effects. The NOEL for this study is 0.4% 2-(octylthio)ethanol in the diet (Powers, M.B., 1961).
In a 21-day dermal toxicity study, New Zealand white rabbits (5/sex/dose) were given repeated dermal applications of technical hydroxyethyl octyl sulfide (100%) in corn oil at doses of 50, 100 or 200 mg/kg, 6 hours/day, 7 days/week for 21 days; the vehicle control group (5/sex) received corn oil only on the same regimen. Treatment had no adverse effect on survival, clinical signs, mean body weights, body weight gain, food consumption, hematology, clinical chemistry, organ weights or gross histopathology. Treatment-related skin reactions were confined mainly to a proportion of animals receiving 100 or 200 mg/kg/day. Dermal reactions included: skin wrinkling in 1 male at 200 mg/kg/day; desquamation in 1 female at the vehicle control, 1 male and 1 female at 50 mg/kg/day, in 3 males and 2 females at 100 mg/kg/day, and in 5 males and 4 females at 200 mg/kg/day; and moderate to severe erythema usually in combination with moderate edema in 1 male and 1 female at the vehicle control and at 50 mg/kg/day, in 4 males and 0 females at 100 mg/kg/day and in 4 males and 2 females at 200 mg/kg/day. Based on these results, for dermal irritation the NOEL was 50 mg/kg/day and the LOEL was 100 mg/kg/day. For systemic toxicity the NOEL was > 200 mg/kg/day; a LOEL was not established (US EPA, 1995).
Justification for classification or non-classification
Based on the available repeat dose toxicity data on 2-(octylthiol)ethanol, no classification under DSD or GHS/CLP is warranted.
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