Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 214-787-5 | CAS number: 1194-65-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Not stated
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- according to guideline
- Guideline:
- other: BBA Merkblatt no. 55
- Deviations:
- yes
- Remarks:
- Test was stopped after 150 days rather than when 50 % of the test material had decomposed. This deviation complies with EPA Guideline 161-1
- GLP compliance:
- yes
- Radiolabelling:
- no
- Analytical monitoring:
- yes
- Buffers:
- - pH: 5, 7 and 9
- Type and final molarity of buffer:
- Composition of buffer:
pH 5: 0.1 mol/L potassium hydrogen phtalate and 0.05 mol/L sodium hydroxide
pH 7: 0.071 mol/L potassium hydrogen phosphate and 0.01 mol/L disodium hydrogen phosphate
pH 9: 0.1 mol/L boric acid, 0.1 mol/L potassium chloride and 0.1 mol/L sodium hydroxide - Details on test conditions:
- TEST SYSTEM
- Type, material and volume of test flasks, other equipment used: closed, non-sterile, all glass vessels
- Sterilisation method: not applicable
- Lighting: none
- Measures taken to avoid photolytic effects: vessels kept in the dark - Duration:
- 150 d
- Temp.:
- 22 °C
- Initial conc. measured:
- 0.007 - 0.009 µg/L
- Number of replicates:
- 2
- Positive controls:
- no
- Negative controls:
- no
- Transformation products:
- not measured
- Key result
- pH:
- 5
- Temp.:
- 22 °C
- DT50:
- > 150 d
- Key result
- pH:
- 7
- Temp.:
- 22 °C
- DT50:
- > 150 d
- Key result
- pH:
- 9
- Temp.:
- 22 °C
- DT50:
- > 150 d
- Details on results:
- RECOVERIES OF TEST MATERIAL
- 7th September 1982: mean recovery 100 % (all pHs)
- 29th September 1982: mean recovery 102 % (all pHs)
- 7th December 1982: mean recovery 102.4 % (all pHs)
- 10th February 1983: mean recovery 100 % (all pHs) - Validity criteria fulfilled:
- not specified
- Conclusions:
- Under the conditions of the test, the hydrolysis of the test material was determined to be >150 days and the test material is considered to be hydrolytically stable.
- Executive summary:
In a GLP compliant hydrolysis conducted in accordance with sound scientific principles and an acceptable guideline (BBA Merkblatt no. 55), the hydrolysis of the test material was determined. Under the conditions of the test, the half-life of the test material was determined to be >150 days at pH 5, 7 and 9 and the test material is considered to be hydrolytically stable.
Reference
Table 1: Results
Concentration of test material (µg/mL) | |||
Days after test start | pH 5 | pH 7 | pH 9 |
0 | 7.24 | 8.90 | 8.93 |
16 | 7.16 | 8.55 | 8.68 |
30 | 7.14 | 8.64* | 8.65 |
60 | 7.04 | 8.57 | 8.55 |
90 | 7.20 | 8.58 | 8.30 |
150 | 6.83 | 8.24 | 8.18* |
* based on one value as the other was regarded as an outlier
The coefficient of variation was calculated from the duplicate determinations and equals 1.6 %. The decomposition was tested, using the first order model, and was significant for all three pH values.
Description of key information
The test material was determined to be a have a half-life of >150 days at pH 5, 7 and 9 and is considered to be hydrolytically stable according to a study performed in line with recognised guideline BBA Merkblatt no. 55.
Key value for chemical safety assessment
Additional information
The key study (Buisman, 1988) was performed in line with GLP and a recognised guideline with a sufficient level of detail to assess the quality of the study. The study was performed to a good standard and was assigned a reliability score of 2 using the principle for assessing data quality as set out in Klimisch (1997) on the basis that the guideline followed was not a standardised guideline although sufficient for the purposes of this study.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.