Reaction products of N,N'-ethane-1,2-diylbis(1,3-propanediamine), cyclohexane, peroxidized 4-butylamino-2,2,6,6-tetramethylpiperidine and 2,4,6-trichloro-1,3,5-triazine

Adsorption / desorption

Link to relevant study record(s)

Reference

Endpoint:

adsorption / desorption: screening

Type of information:

experimental study

Adequacy of study:

other information

Study period:

1997-10-15 - 1997-11-06

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: GLP guideline study (OECD test guideline 106)

Qualifier:

according to guideline

Guideline:

OECD Guideline 106 (Adsorption - Desorption Using a Batch Equilibrium Method)

GLP compliance:

yes

Type of method:

batch equilibrium method

Media:

other: Calcium Chloride Matrix

Radiolabelling:

no

Executive summary:

Based on the experiments and analysis of the test item performed and due to an analytical method detection limit equal to 0.050 mg/L it is concluded that a reliable method is not available in the 0.010 mg/L range for the test item as required in the 106 OECD guideline. In addition, the 106 OECD guideline indicates that the Adsorption/Desorption study must be performed at one half water solubility. It was determined from a reported water solubility value of less than 0.040 mg/L that the Adsorption/Desorption study would have to be conducted at 0.020 mg/L, which is below the analytical detection limit of 0.050 mg/L. Therefore, an Adsorption/Desorption study following OECD Guideline 106 would not be applicable for the test item. Based on the analytical methodology presented and the results demonstrating a water solubility at less than 0.040 mg/L, a waiver for the Adsorption/Desorption study is appropriate to fulfill regulatory requirements. In addition, the OECD TG 106 indicates thta the study must be performed at one half of the water solubility which is determined to be < 0.040 mg/L. Meaning that the study would have to be conducted at 0.020 mg/L which is far below the LOD of 0.050 mg/L.

Description of key information

In accordance with Regulation 1907/2006 (EC) Annex XI, paragraph 2
adsorption/desorption study was not conducted as the study is 
technically not feasible. Based on the experiments and analysis of the 
test item performed and due to an analytical method detection limit equal to 0.050 mg/L it is
concluded that a reliable method is not available in the 0.010 mg/L range 
for the test item as required in the 106 OECD guideline. In addition, 
the 106 OECD guideline indicates that the Adsorption/Desorption study 
must be performed at one half water solubility. 
It was determined from a reported water solubility value of 
less than 0.040 mg/L that the Adsorption/Desorption study would have to be 
conducted at 0.020 mg/L, which is below the analytical detection limit of 
0.050 mg/L. Therefore, an Adsorption/Desorption study following OECD 
Guideline 106 would not be applicable for the test item. 
Based on the analytical methodology presented and the results demonstrating 
a water solubility at less than 0.040 mg/L, a waiver for the 
Adsorption/Desorption study is appropriate to fulfill regulatory requirements. 
For futher details please also look at the attached documents provided in the waiver section.

Additional information