Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
skin sensitisation: in vivo (non-LLNA)
Type of information:
other: summary of experimental results
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1986
Report date:
1986

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
The paper presented a survey of the toxicological properties of the tributyltin compounds with the emphasis on data from their own testing laboratory. It’s main aim was to give an assessment of possible health hazards which may arise from contact at the work-place during manufacturing or use of wood-preservatives containing these compounds. The final part of the assessment consisted of assessing the risk which might originate from the use of such formulations for the protection of wood in interiors of dwellings.

Data concerning the potential for sensitisation by contact with TBTO to the skin is listed as a short abstract.
GLP compliance:
not specified
Type of study:
other: A review of existing data

Test material

Constituent 1
Chemical structure
Reference substance name:
Bis(tributyltin) oxide
EC Number:
200-268-0
EC Name:
Bis(tributyltin) oxide
Cas Number:
56-35-9
Molecular formula:
C24H54OSn2
IUPAC Name:
tributyl[(tributylstannyl)oxy]stannane
Details on test material:
Listed as Tributyltin oxide (TBTO) , with the synonyms bis (tri-n-butyltin) Oxide or hexa-n-butyldistannoxane.

In vivo test system

Test animals

Species:
guinea pig
Strain:
not specified
Sex:
not specified

Study design: in vivo (non-LLNA)

Induction
Concentration / amount:
No information
Challenge
Concentration / amount:
No information
No. of animals per dose:
No information
Details on study design:
No information
Challenge controls:
No information
Positive control substance(s):
not specified

Results and discussion

Positive control results:
No data

In vivo (non-LLNA)

Results
Remarks on result:
no indication of skin sensitisation

Applicant's summary and conclusion

Interpretation of results:
other: Not classified according to EU criteria
Conclusions:
In this review article, previous data indicates that TBTO is not sensitizing but local irritatation was reported to make the performance of the test difficult.
Executive summary:

In this review study, dermal sensitization from tri-n-butyltin oxide (TBTO) was not observed in the maximization test in guinea pigs in previously available literature. No indication of skin senstizing effect was observed; however the test was made difficult by the locally irritating potential of tributyltin compounds.