Registration Dossier
Registration Dossier
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EC number: 284-851-5 | CAS number: 84988-61-4
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
TOXICOKINETIC BEHAVIOUR
Physico-chemical properties:
Isononyl phosphate (VPXZ100) is a yellow liquid at room temperature and pressure. The substance VPXZ100 consists principally of the mono and diester: isononyl dihydrogen phosphate (CAS 27253-57-2; molecular weight 224.2 g/mol) and diisononyl hydrogen phosphate (CAS 27253-58-3; molecular weight 350.5 g/mol), respectively. It was found that 65.5% of the test item had a log10 Pow of 1.09; whereas, the remaining 34.5% had a log10 Pow in the range 3.83 to 4.28. It is most likely that these values come from the mono-ester and di-esters, respectively. The substance is not water soluble but forms stable emulsions. The vapour pressure value is 0.00013 Pa at 25 degC, which is indicative that the substance is not volatile at room temperature and pressure, therefore inhalation exposures are not a concern.
Absorption:
There are no directly measured ADME data by any route for VPXZ100.
Oral: The data on the read across analogue substance 2-ethylhexyl phosphate indicates that alkyl phosphate esters are readily available via the oral route.
Inhalation: no data, as the substance is not volatile and not expected to be inhaled.
Dermal: VPXZ100 is classified as corrosive. Damage to the skin barrier will allow this substance to absorb into the systemic circulation. Given the physicochemical properties of this substance, it is likely that skin absorption into the systemic circulation can occur. It is expected that the extent of absorption will rely heavily on the vehicle in which the substance is solubilised or emulsified.
Distribution
There are no specific data on differential distribution to organs.
Metabolism:
There is no information on the specific metabolism of isononyl phosphate. VPXZ100 may undergo hydrolysis to isononanol and phosphate. There is no evidence from in vitro genotoxicity studies to suggest that metabolism plays a role in the genotoxic properties of alkyl phosphate esters.
Excretion:
No data are available to determine the pathways or extent of excretion.
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