Tetrahydro-3-methylfuran

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Study period:

11/15/85 - 12/4/85

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Comparable to guidline study with accepatable restrictions, e.g. Study did not attempt concentrations over 6700 ppm.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1985

Report date:

1985

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 433 draft (Acute Inhalation Toxicity: Fixed Concentration Procedure) (not officially approved)

GLP compliance:

yes

Test type:

fixed concentration procedure

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Tetrahydro-3-methylfuran

EC Number:

236-537-4

EC Name:

Tetrahydro-3-methylfuran

Cas Number:

13423-15-9

Molecular formula:

C5H10O

IUPAC Name:

tetrahydro-3-methylfuran

Details on test material:

Purity = 99.4%
250 ppm BHT added as stabilizer
tetrahydrofuran listed as contaminant

Test animals

Species:

rat

Strain:

Crj: CD(SD)

Sex:

male

Details on test animals or test system and environmental conditions:

Groups of 6 rats , 8 weeks old and weighing between 225 and 270 grams were restrained in perforated, stainless steel cylinders with conical nose pieces. Each group was exposed nose-only for a single. 4- hour period to a vapor atmosphere of 30 mehtyltetrahydrofuran in air. Rats were weighed prior to exposure, and were observed for clinical signs of toxicity during exposure.

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

nose only

Details on inhalation exposure:

GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: animals restrained in perforated, stainless stell cylinder with conical nose pieces
- Method of holding animals in test chamber:animals restrained in perforated, stainless stell cylinder
- Treatment of exhaust air: drawn through a cold trap and MSA cartridge filter prior to being discharged int the hood.
- Temperature, humidity, pressure in air chamber: temperature ranged between 29-31oC, relative humidity ranged from 78-82%

TEST ATMOSPHERE
atmospheric concentration determined at 30-min intervals during exposure by gas chromatograpgh equiped with a flame ionization detector.
- Samples taken from breathing zone: yes

Analytical verification of test atmosphere concentrations:

yes

Remarks:

GC chromatograph

Duration of exposure:

4 h

Concentrations:

900, 1600, 3200 and 6700 ppm

No. of animals per sex per dose:

6

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: daily
- Necropsy of survivors performed: no
:

Results and discussion

Effect levels

Sex:

male

Dose descriptor:

other: ALC

Effect level:

> 6 700 ppm

Based on:

test mat.

Remarks on result:

other: Approximate Lethal Concentration (ALC) is the lowest atmospheric concentration that caused death in 1 or more rats.

Mortality:

Under the conditions of this test, no rats died following exposure to 3-methyltetrahydrofuran at concntrations up to 6700 ppm.

Clinical signs:

other: During or immediately following exposure, rats in all groups had red nasal or ocular discharges, effects common in rats under restraint. Rats exposed to 3200 ppm and rats exposed to 6700 ppm had a diminished startle response during exposure. In addition,

Body weight:

During the postexposure period, rats exposed to 900, 1600 or 3200 ppm had minimal weight loss (average less than 3%) 1 day after exposure, followed by normal weight gain. Rats exposed to 6700 ppm lost a average of 8% of initial body weight.

Any other information on results incl. tables

Acute Inhalation Concentration (ppm)			Mortality
Mean	S.D	Range	(# Deaths / # Exposed)
900	34	840 - 950	0/6
1600	120	1500 - 1900	0/6
3200	160	2900 - 3400	0/6
6700	470	6000 - 7400	0/6

Applicant's summary and conclusion

Interpretation of results:

practically nontoxic

Remarks:

Migrated information

Conclusions:

Under the conditions of this study, the lowest atmospheric concentration that caused death in 1 or more rats (ALC) for 3-methyltetrahydrofuran was greater than 6700 ppm and is considered to have very low toxicity on the acute inhalation basis (ALC > 5000 ppm)

Executive summary:

Groups of 6 male Crl CD (SD) BR rats were exposed to vapor atmosphere of 3 -methyltetrahydrofuran for a single, 4 hour period. Under the conditions of this test, the lowest atmospheric concentration tested that caused the death of 1 or more rats, either on the day of exposure or within 14 days post exposure for 3-methyltetrahydrofuran was greater than 6400 ppm. This material is considered to have a very low toxicity on an acute inhalation basis.