Registration Dossier
Registration Dossier
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EC number: 235-730-0 | CAS number: 12627-14-4
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
EC50 (72 h, biomass): 207 mg/L (Scenedesmus subspicatus), RA sodium silicate
EC50 (72 h, growth rate): > 345.4 mg/L (Scenedesmus subspicatus), RA sodium silicate
EC0(72h, biomass): 35 mg/L (Scenedesmus subspicatus), RA sodium silicate
However, for the purpose of risk assessment and as explained in the section on the calculation of Predicted No Effect Concentrations, the PNEC is derived from the ubiquitous SiO2 background concentration in freshwater in Europe, which is 7.5 mg/L.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 207 mg/L
- EC10 or NOEC for freshwater algae:
- 35 mg/L
Additional information
Tests with silicic acid, lithium salt are not available. Therefore, data from a test with a related substance were considered. The effects of sodium silicate (MR 3.0, 34.54 wt%) on the algae Scenedesmus subspicatus were tested in a GLP guideline study according to OECD guideline 201 (Rieche 1995). The 72 h EC50 based on biomass was 207 mg active matter/L at pH 8.2 - 9.5. The EC50 for growth rate was determined as > 345.4 mg active matter/L, the highest concentration tested. An EC0/NOEC for biomass, the more sensitive parameter, was derived at 35 mg active matter/L.
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