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EC number: 201-089-0 | CAS number: 78-16-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
NOEC (14 d): 30.4 mg/L (Toxicity control of ready biodegradation test OECD 301B)
Key value for chemical safety assessment
Additional information
Studies on the toxicity
of 2-ethyl-2-[[(1-oxoheptyl)oxy]methyl]propane-1,3-diyl bisheptanoate
(CAS 78-16-0) to aquatic microorganisms are not available. Therefore the
assessment of the toxicity to microorganisms is based on the NOEC
determined in the toxicity control reported in the study on ready
biodegradability. This approach is suitable for substances with high
degrading rates or no degradation inhibition in the positive control in
ready biodegradability tests. This is in accordance with the Guidance on
information requirements and chemical safety assessment (Chapter R.7b:
Endpoint specific guidance, ECHA 2012).
A substance can be assumed to be not inhibitory to aquatic
microorganisms, if in the toxicity control of a ready biodegradation
test more than 25% degradation based on CO2 evolution occurred within 14
days (OECD guideline 301). For
2-ethyl-2-[[(1-oxoheptyl)oxy]methyl]propane-1,3-diyl bisheptanoate (CAS
78-16-0) a biodegradation test according to OECD guideline 301B is
available (Muckle, 2009). The test includes a toxicity control, which
contains 30.4 mg/L of the test substance and 26.8 mg/L of the reference
material (Anilin). The toxicity control attained 41.8% degradation after
4 days of incubation (80.4% after 14 d). Hence, the substance is not
toxic to aquatic microorganisms and the test item concentration of 30.4
mg/L in the toxicity control can be used as NOEC. As it can be seen in
the data matrix of the category justification in section 13 and the
overall endpoint summary IUCLID 6.1, all reliable data in the category
support the hazard assessment of each category member by showing a
consistent pattern of results, i.e. no microbial inhibition
and no toxic effects were observed to aquatic organisms up to the limit
of water solubility.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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