Registration Dossier
Registration Dossier
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EC number: 252-650-1 | CAS number: 35636-63-6
Toxicological Summary
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - workers
Worker DNEL has not been derived for Pigment Yellow 175 because the substance did not cause relevant toxictiy in any test performed according to the information requirements.
- the substance did not cause lethal effects after administration of a single oral dose of 15000 mg/kg or in a test for acute toxicity after inhalation exposure up to the highest achievable concentration tested in rats,
- the substance is not irritating and does not have to be classified as eye or skin irritant,
- the substance does not have to be classified as skin sensitizing based on the findings in a test with guinea pigs,
- the substance caused no relevant systemic toxic effects in a subacute oral study in rats (NOAEL >= 1000 mg/kg/day),
- the absence of adverse effects in the above-mentioned toxicity endpoint tests indicates that the substance does not interact with living cells/tissues, and
- it is unlikely that the substance becomes systemically bioavailable due to its extremely low solubility in water and low solubility in n-octanol. The substance is not likely to be systemically available after oral, dermal or inhalation exposure.
Therefore no DNEL for systemic effects has been derived.
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - General Population
DNEL has not been derived for Pigment Yellow 175 because the substance did not cause relevant toxictiy in any test performed according to the information requirements.
- the substance did not cause lethal effects after administration of a single oral dose of 15000 mg/kg or in a test for acute toxicity after inhalation exposure up to the highest achievable concentration tested in rats,
- the substance is not irritating and does not have to be classified as eye or skin irritant,
- the substance does not have to be classified as skin sensitizing based on the findings in a test with guinea pigs,
- the substance caused no relevant systemic toxic effects in a subacute oral study in rats (NOAEL >= 1000 mg/kg/day,
- the absence of adverse effects in the above-mentioned toxicity endpoint tests indicates that the substance does not interact with living cells/tissues, and
- it is unlikely that the substance becomes systemically bioavailable due to its extremely low solubility in water and low solubility in n-octanol. The substance is not likely to be systemically available after oral, dermal or inhalation exposure.
Therefore, no DNEL for systemic effects has been derived.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
