Registration Dossier
Registration Dossier
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EC number: 700-103-7 | CAS number: -
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2007
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 007
- Report date:
- 2007
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
- GLP compliance:
- yes (incl. QA statement)
- Type of study:
- mouse local lymph node assay (LLNA)
Test material
- Reference substance name:
- reaction mass of (2S,5R)-2-tert-butyl-5-methyl-2-propyl-2,5-dihydrofuran and (2S,5S)-2-tert-butyl-5-methyl-2-propyl-2,5-dihydrofuran
- EC Number:
- 700-103-7
- Molecular formula:
- C12H22O
- IUPAC Name:
- reaction mass of (2S,5R)-2-tert-butyl-5-methyl-2-propyl-2,5-dihydrofuran and (2S,5S)-2-tert-butyl-5-methyl-2-propyl-2,5-dihydrofuran
Constituent 1
In vivo test system
Test animals
- Species:
- mouse
- Strain:
- CBA
- Sex:
- female
Study design: in vivo (LLNA)
- Vehicle:
- acetone/olive oil (4:1 v/v)
- Concentration:
- 25%, 50% and 100%
- No. of animals per dose:
- 5
Results and discussion
In vivo (LLNA)
Resultsopen allclose all
- Parameter:
- SI
- Remarks on result:
- other: Test item: 0% S.I: 1.00 Test item: 25% S.I: 2.02 Test item: 50% S.I: 3.24 Test item: 100% S.I: 4.30
- Parameter:
- other: disintegrations per minute (DPM)
- Remarks on result:
- other: Test item: 0% DPM: 917.8 Test item: 25% DPM: 1854.9 Test item: 50% DPM: 2975.9 Test item: 100% DPM: 3947.6
Applicant's summary and conclusion
- Interpretation of results:
- sensitising
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The test item was found to be a skin sensitiser and an EC3 value of 45.1% (w/v) was derived
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