Registration Dossier
Registration Dossier
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EC number: 270-434-5 | CAS number: 68440-09-5
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
NOEC (14 d) = 12.9 mg/L (toxicity control, OECD 301B)
Key value for chemical safety assessment
Additional information
One study investigating the toxicity offatty acids, lanolin, esters with pentaerythritol (CAS 68440-09-5)is available. The data were based on the inhibition control of a ready biodegradability study (Clarke, 2012). In this study according to OECD 301B, EU Method C.4-C and EPA OPPTS 835.3110 a 14 d-NOEC of 12.9 mg/L could be determined, based on the toxicity control. One Study investigating the biodegradation offatty acids, lanolin, esters with pentaerythritol (CAS 68440-09-5), was tested in an in a CO2 Evolution Test according to OECD guideline 301B using domestic activated sludge as inoculum. This test also consisted of a toxicity control. The toxicity control was tested at a test concentration of 12.9 mg/L, equivalent to 10 mg carbon/L. The toxicity control attained 36% degradation after 2 days of incubation (60% after 14 days). In accordance with the OECD Guideline 301 if in a toxicity test, containing both the test substance and a reference compound, more than 25% degradation (based on total ThOD or ThCO2) occurred within 14 days, the test substance can be assumed to be non inhibitory to microbial organisms.
It can therefore be concluded thatfatty acids, lanolin, esters with pentaerythritol (CAS 68440-09-5)will not exhibit effects to aquatic microorganism up to the limit of water solubility. The test item concentration in the toxicity control of 12.9 mg/L can be used as NOEC value for the toxicity to aquatic microorganisms.As it can be seen in the data matrix of the category justification in section 13 and the overall endpoint summary IUCLID 6.1, all reliable data in the category support the hazard assessment of each category member by showing a consistent pattern of results, i.e. no microbial inhibition and no toxic effects were observed to aquatic organisms up to the limit of water solubility.
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