Registration Dossier
Registration Dossier
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EC number: 939-489-9 | CAS number: -
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
The substance is chronically not toxic to aquatic invertebrates.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 4.7 mg/L
Additional information
The long-term toxicity to aquatic invertebrates was investigated in a GLP study according to OECD 211 using Daphnia magna test species (BASF SE 2013; report no. 51E0117/10E132). The test concentrations were analytically determined. Reproduction was the most sensitive endpoint. The 21 -d NOEC was 3.2 mg/L, the EC10 was 4.7 mg/L (nominal).
According to the Guidance on information requirements and chemical safety assessment Chapter R.10: Characterisation of dose [concentration]-response for environment "an EC10 for a long-term test which is obtained using an appropriate statistical method (usually regression analysis) will be used preferentially. [...] There has been a recommendation within OECD in 1996 to phase out the use of the NOEC, in particular as it can correspond to large and potentially biologically important magnitudes of effect. The advantage of regression method for the estimation of ECx is that information from the whole concentration-effect relationship is taken into account and that confidence intervals can be calculated. These methods result in an ECx, where x is a low effect percentile (e.g. 5-20%). It makes results from different experiments more comparable than NOECs." Therefore, the EC10 instead of the NOEC has been used to derive the classification and the relevant PNECs.
Based on the experimentally determined EC10 the substance is assessed to be chronically not toxic to aquatic invertebrates.
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