Registration Dossier
Registration Dossier
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EC number: 619-566-0 | CAS number: 848301-65-5
Adsorption / desorption
Administrative data
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP-study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 006
- Report date:
- 2006
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))
- Deviations:
- yes
- Principles of method if other than guideline:
- As the test material had a high affinity for the HPLC column stationary phase, it was necessary to increase the methanol content of the mobile phase
to 100% to elute the test material. This was performed at a time greater than the retention time of DDT (25 minutes) such that all components
eluted by the amended mobile phase shared a common adsorption coefficient value, that of greater than the highest calibration standard. To allow
detection of the test material, fractions of eluent were collected from the HPLC instrument for analysis by gas chromatography (GC). - GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Safepharm Laboratories Limited
- Type of method:
- HPLC estimation method
- Media:
- other: HPLC column: Genesis CN 4µ
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
- Radiolabelling:
- no
Results and discussion
Adsorption coefficientopen allclose all
- Type:
- Koc
- Value:
- > 427 000
- Type:
- log Koc
- Value:
- > 5.63
Any other information on results incl. tables
see attached full study report at "4.2 Melting Point" [ Attachment 6, page 29-38]
Applicant's summary and conclusion
- Validity criteria fulfilled:
- not specified
- Conclusions:
- adsorption coefficient 111 to >4.27 x 10e5, log10 Koc 2.05 to >5.63, using the HPLC screening method, Method C19 of Commission Directive 2001/59/EC). By fraction collection and subsequent GC analysis, 91.4% of the test material had a log10 Koc value greater than 5.63, calculated from GC
normalisation data.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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