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EC number: 240-986-1 | CAS number: 16924-00-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics
- Type of information:
- other: Handbook data
- Adequacy of study:
- supporting study
- Study period:
- Not stated
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Peer reviewed handbook citing toxicological data as found in the literature. Information provided is based on a suitable read-across substance.
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Metal Toxicity in Mammals 2 Chemical Toxicity of Metals and Metalloids
- Author:
- Venugopal B & Luckey T D
- Year:
- 1 978
- Bibliographic source:
- Ch. 5 pg. 205-6 and 229-231
Materials and methods
- Principles of method if other than guideline:
- Data is taken from a handbook and therefore has no specific information regarding methodology.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Potassium tantalate
- IUPAC Name:
- Potassium tantalate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Details on study design:
- A non standard method was used; 8 mg of potassium tantalate was mixed with mixed with NaCl and introduced to rats via a stomach tube.
Results and discussion
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- Ta compounds display low gastrointestinal solubility in rats.
- Details on distribution in tissues:
- Retention of Ta in mammalian tissue is more prolonged in comparison with other metals in Group V. The order of retention in ascending order: bones, gastrointestinal tract, pelt, muscle, liver, kidneys, testes then spleen. Tantalum held in the bones accounts for 40% of the body content (Fleshman et al., 1971).
There are no reports of Ta accumulation in tissue.
There are no reported homeostatic excretory pathways.
- Details on excretion:
- Soluble potassium tantalate was eliminated in three phases; rapid elimination of unabsorbed tantalate, slow elimination of loosely bound tantalate in the tissue, and a 3-4 day elimination of minute quantities of tightly bound tantalum.
Metabolite characterisation studies
- Metabolites identified:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): bioaccumulation potential cannot be judged based on study results
Under the conditions of the test potassium tantalate is excreted within the faeces in 3 phases, when fed to rats. Bioretention can be prolonged in comparison to other Group V Metals, however specific information is not given. Bioaccumulation is greatest in the bones, then in descending order; gastrointestinal tract, pelt, muscle, liver, kidneys, testes then spleen. Again no specific data is presented about bioaccumulation. It is also stated that gastrointestinal absorption of Ta salts is relatively low in rats. - Executive summary:
Under the conditions of the test potassium tantalate is excreted within the faeces in 3 phases, when fed to rats; rapid excretion of unabsorbed tantalate, slow elimination of loosely bound tantalum in tissues and a 3 to 4 day elimination of minute quantities of tightly bound tantalum.
Bioretention can be prolonged in comparison to other Group V Metals, however specific information is not given. Bioaccumulation is greatest in the bones, then in descending order; gastrointestinal tract, pelt, muscle, liver, kidneys, testes then spleen; again no specific data is presented about bioaccumulation. It is also stated that gastrointestinal absorption of Ta salts is relatively low in rats.
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