2-morpholinoethanol

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1967-11-16 tpo 1967-12-12

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Non GLP, predated OECD guideline, but scientifically fully acceptable and well documented.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1968

Report date:

1968

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

BASF-Test: acute inhalation toxicity with rats exposed to a saturated atmosphere for 8 h.

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

2-morpholinoethanol

EC Number:

210-734-5

EC Name:

2-morpholinoethanol

Cas Number:

622-40-2

Molecular formula:

C6H13NO2

IUPAC Name:

2-(morpholin-4-yl)ethan-1-ol

Test animals

Species:

rat

Strain:

not specified

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Age at study initiation: young adult

Administration / exposure

Route of administration:

inhalation

Type of inhalation exposure:

whole body

Vehicle:

air

Details on inhalation exposure:

GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: Water bath, 200 L air/h, 20°C, saturated atmosphere
The vapors were generated by bubbling 200 l/h air through a substance column of about 5 cm above a fritted glass disc in a glass cylinder.

Analytical verification of test atmosphere concentrations:

no

Duration of exposure:

8 h

Concentrations:

concentration in air not measured (saturated concentration)

No. of animals per sex per dose:

6 male and 6 female animals

Control animals:

no

Details on study design:

- Duration of observation period following administration: 7 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, gross pathology, body weight (at start of study)

Statistics:

none

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LC0

Effect level:

other: saturated atmosphere

Based on:

test mat.

Exp. duration:

8 h

Remarks on result:

other: no effects (saturated athomsphere)

Mortality:

no mortality

Clinical signs:

other: eye secretion

Body weight:

no data

Gross pathology:

One aminal: morphological liver damage

Other findings:

none