Registration Dossier
Registration Dossier
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EC number: 432-840-2 | CAS number: 220926-97-6
Acute Toxicity: inhalation
Some information in this page has been claimed confidential.
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 999
- Report date:
- 1999
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.1300 (Acute inhalation toxicity)
- Deviations:
- no
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- no
- Principles of method if other than guideline:
- Not applicable
- Test type:
- standard acute method
- Limit test:
- no
Test material
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- nose only
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- 3.97 mg/L air (analytical)
- 95% CL:
- >= 2.25 - <= 5.69
- Exp. duration:
- 4 h
- Sex:
- female
- Dose descriptor:
- LC50
- Effect level:
- 7.42 mg/L air (analytical)
- 95% CL:
- >= -4.75 - <= 19.6
- Exp. duration:
- 4 h
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- 5.08 mg/L air (analytical)
- 95% CL:
- >= 1.9 - <= 8.27
- Exp. duration:
- 4 h
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- 2.79 other: mg/L (respirable component, i.e. < 7µm)
- 95% CL:
- >= 1.73 - <= 3.85
- Exp. duration:
- 4 h
- Sex:
- female
- Dose descriptor:
- LC50
- Effect level:
- 5.03 other: mg/L (respirable component, i.e. < 7 µm))
- 95% CL:
- >= -2.47 - <= 12.53
- Exp. duration:
- 4 h
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- 3.56 other: mg/L (respirable component, i.e. < 7 µm)
- 95% CL:
- >= 1.47 - <= 5.64
- Exp. duration:
- 4 h
Any other information on results incl. tables
Table 7.2.2/3: lung weights in decedents and 14 days after exposure in survivors
Group |
Lung weight |
|||
Males |
Females |
|||
Decedent |
Survivor |
Decedent |
Survivor |
|
Control |
|
1.77 ± 0.100 |
|
1.31 ± 0.090 |
0.77 mg/L |
|
1.81 ± 0.119 |
1.43 ± 0.116 |
|
2.26 mg/L |
|
1.83 ± 0.197 |
2.89 |
1.50 ± 0.115 |
5.30 mg/L |
1.75 |
3.66 ± 0.429 |
3.18 |
2.47 ± 0.266 |
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
