Registration Dossier
Registration Dossier
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EC number: 420-960-8 | CAS number: 77214-82-5 JOF 2822 5F; JOF 2822 5FL; JOF 4443
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Iron (III) tris(4-methylbenzenesulfonate)
- EC Number:
- 420-960-8
- EC Name:
- Iron (III) tris(4-methylbenzenesulfonate)
- Cas Number:
- 77214-82-5
- Molecular formula:
- C21 H21 Fe O9 S3
- IUPAC Name:
- iron(3+) tris(4-methylbenzene-1-sulfonate)
- Test material form:
- solid: pellets
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Doses:
- 1500 mg/kg bw
2000 mg/kg bw
2500 mg/kg bw - No. of animals per sex per dose:
- 5
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 2 350 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Male: 1500 mg/kg bw; Number of animals: 5; Number of deaths: 0
Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 2
Male: 2500 mg/kg bw; Number of animals: 5; Number of deaths: 2
Female: 1500 mg/kg bw; Number of animals: 5; Number of deaths: 1
Female: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 1
Female: 2500 mg/kg bw; Number of animals: 5; Number of deaths: 2 - Clinical signs:
- other: As signs of intoxication piloerection was observed in all dose groups, from 2000 mg/kg additionally sedation and increased salivation. Symptoms occured 30 min after application and stayed up to day 11.
- Gross pathology:
- Deads in 2000 and 2500 mg/kg:
The stomach was filled with yellow-brownish, partially solid mass, the stomach and intestine mucousa was redened. In each one female and one male of 2000 mg/kg the abdomen was filled with dark yellow liquid. In the female died at 1500 mg/kg the stomach was filled with an aqueous liquid, the mucousa reded and the intestine content black discoloured.
All animals which were killed at the end of the study did not show any affects.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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