Registration Dossier
Registration Dossier
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EC number: 696-130-6 | CAS number: 1364681-45-7
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
Significant accumulation in organisms is not to be expected.
Key value for chemical safety assessment
Additional information
No experimentally derived BCF is available for the present substance.
However, the logKow was calculated to be 2.55.
Additionally, in a weight of evidence approach several QSAR models were used to derive the BCF for the main components of the test substance:
US EPA T.E.S.T v4.0.1 using the consensus method resulted in a BCF of 93.58 - 132.37.
US EPA EPISuite v4.10 (BCF BAF v3.01) revealed a BCF of 3.162 - 56.23 L/kg wet-wt using the measured logPow of 4.8 - 7.36.
CATALOGIC v5.11.5 (BCF base-line model v2.05) resulted in a BCF of 59.42 - 176.24 with all mitigating factors applied. Even though the structural domain was correct with only min. 56.52% (max. 43.48% unknown) the results support the overall conclusion in a weight of evidence.
VEGA BCF model (CAESAR) version 2.1.13 resulted in a predicted BCF of 122 - 123 L/kg (logBCF = 0.52). Likewise CATALOGIC the test substance was out of domain. Nevertheless, the results can be used in the weight of evidence to give an indication if the test substance has a bioaccumulative potential.
In overall conclusion, regarding all available information the test item is not bioaccumulative according to PBT criteria.
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