Registration Dossier
Registration Dossier
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EC number: 922-114-8 | CAS number: -
Endpoint summary
Administrative data
Description of key information
Additional information
There are no data available on the aquatic toxicity of hydrocarbons, C5-C6, n-alkanes, isoalkanes, <5% n-hexane. However, there are reliable data available considered suitable for read-across using the analogue approach.
The target substance is a hydrocarbon solvent with carbon numbers in the range of C5 to C6. The main constituents of the mixed solvent consist of about 43% of C6 species and about 57% of C5 species. n-Hexane is only present in concentrations < 5% of the total volume.
Taking into account all available data, animal and human toxicity data as well as environmental fate and effects data show that source substances have a similar (eco-)toxicological and environmental fate properties as the target substance.
Therefore, read-across is performed based on an analogue approach (for details please refer to the analogue justification which is attached in section 13 of the technical dossier).
For a number of analogue substances the aquatic toxicity was estimated by a QSAR, using the Petrotox computer model (v 3.04), which combines a partitioning model used to calculate the aqueous concentration of hydrocarbon components as a function of substance loading with the Target Lipid Model used to calculate acute and chronic toxicity of non-polar narcotic chemicals. Petrotox computes toxicity based on the summation of the aqueous-phase concentrations of hydrocarbon block(s) that represent a hydrocarbon substance and membrane-water partition coefficients K(MW) that describe the partitioning of the hydrocarbons between the water and organism.
In addition to the QSAR calculations some reports from read-across substances are available presenting experimental data.
Reliable studies reporting the most critical values per endpoint were chosen as key studies, regardless if QSAR or experimental result. Aquatic toxicity effect values are in the range of 2 to 11 mg/L with a short-term LC50 of 4.26 mg/L for fish with pentane, a chronic fish NOELR of 2.8 mg/L with hexane, an acute invertebrate EC50 of 2.7 mg/L with pentane, a long-term invertebrate NOELR of 4.888 mg/L with hexane, an algae EC50 of 10.7 mg/L and a NOEC of 2.04 mg/L with pentane, and an EL50 of 4.888 mg/L for toxicity to microorganisms with hexane and Hydrocarbons, C6, n-alkanes, isoalkanes, cyclics, n-hexane.
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