5-(Acetyl-(3-(acetyl-(3,5-bis(2,3-dihydroxypropylcarbamoyl)-2,4,6-triiodophenyl)amino)-2- hydroxypropyl)amino)-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodobenzene-1,3-dicarboxamide; 5,5'-((2-Hydroxytrimethylene)bis(acetylimino))bis(N,N'-bis(2,3-dihydroxypropyl)-2,4,6- triiodoisophthalamide);

Short-term toxicity to aquatic invertebrates

Administrative data

Endpoint:

short-term toxicity to aquatic invertebrates

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1.6-3.6.1992 and 10.6-13.6.1992

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: The study and data are well documented and scientifically acceptable.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1992

Report date:

1992

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)

GLP compliance:

not specified

Test material

Reference

Name:

Unnamed

Type:

Constituent

Test organisms

Test organisms (species):

Daphnia magna

Study design

Total exposure duration:

24 h

Results and discussion

Effect concentrations

Duration:

24 h

Dose descriptor:

EC50

Effect conc.:

> 2 500 mg/L

Applicant's summary and conclusion

Executive summary:

The product has a low toxicity to the aquatic organisms tested. The calculated EC50 and LC50 values show that all products had low toxic effects on daphnia. For Iodixanol, sufficient immobilisation for calculation of EC50 was not obtained in the concentration range tested. Testing at higher concentrations was complicated due to precipitation in the test solutions and was considered unnecessary because of low toxicity.