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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Directive 84/449/EC, B.1
GLP compliance:
yes
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Hexasodium tungstate hydrate
EC Number:
412-770-9
EC Name:
Hexasodium tungstate hydrate
Cas Number:
12141-67-2
Molecular formula:
Na6 H2 W12 O40 . xH2O
IUPAC Name:
hydrate hydrogen oxygen sodium hydride tungsten

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
water

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
1 715 mg/kg bw
Based on:
test mat.
Mortality:
Male: 5000 mg/kg bw; Number of animals: 5; Number of deaths: 5
Male: 2800 mg/kg bw; Number of animals: 5; Number of deaths: 5
Male: 1580 mg/kg bw; Number of animals: 5; Number of deaths: 1
Female: 5000 mg/kg bw; Number of animals: 5; Number of deaths: 5
Female: 2800 mg/kg bw; Number of animals: 5; Number of deaths: 5
Female: 1580 mg/kg bw; Number of animals: 5; Number of deaths: 2
Clinical signs:
other: Signs of toxicity related to dose levels: 5000 mg/kg: Lethargy, hunched posture and tachypnoea 2800 mg/kg: Lethargy, piloerection, ataxia and pale skin 1580 mg/kg: Lethargy, piloerection and hunched posture Although some of the animals that died showed s
Gross pathology:
Effects on organs:
5000 mg/kg: Haemorrhages in the glandular stomach, glandular stomach dark red, lungs dark red, swollen intestine.
2800 mg/kg: haemorrhages in the glandular stomach or lungs, lungs and glandular stomach red in colour, pale liver, pale kidneys, pale lungs, bloody liquid inthe urinary bladder.
1580 mg/kg: Pale liver, pale kidneys, red lungs

Applicant's summary and conclusion

Interpretation of results:
harmful
Remarks:
Migrated information Criteria used for interpretation of results: EU