Registration Dossier
Registration Dossier
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EC number: 607-088-5 | CAS number: 224785-90-4
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2000
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- shake-flask method to: flask method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Type:
- log Pow
- Partition coefficient:
- 2.5
- Temp.:
- 23 °C
- pH:
- ca. 10
- Conclusions:
- The experimental determined logPow of the substance is 2.5 at 23°C and pH 10.
- Executive summary:
Determined according to the guideline EU Method A.8 (Partition Coefficient), the logPow of the substance was 2.5 at 23°C and pH10. Analysis was performed via HPLC.
Reference
| Test no. | pH value | volume | octanol phase | buffer phase | partition coefficient | ||||
| Buffer phase | octanol mL | buffer mL | conc. mg/mL | amount mg | conc. mg/mL | amount mg | single value | mean value | |
| 1a | 10 | 5 | 245 | 1.5841 | 7.921 | 0.00557 | 1.365 | 284.4 | |
| 1b | 10 | 5 | 245 | 1.5751 | 7.876 | 0.00543 | 1.330 | 290.1 | 287.3 |
| 2a | 10 | 10 | 240 | 0.8714 | 8.714 | 0.00298 | 0.715 | 292.4 | |
| 2b | 9.9 | 10 | 240 | 0.8744 | 8.744 | 0.00296 | 0.710 | 295.4 | 293.9 |
| 3a | 9.9 | 20 | 230 | 0.4511 | 9.022 | 0.00153 | 0.352 | 294.8 | |
| 3b | 10.1 | 20 | 230 | 0.4533 | 9.066 | 0.00153 | 0.352 | 296.3 | 295.6 |
Inserted amount of the substance: 9.395 mg/L
mean value: Pow = 292
Description of key information
The experimentally determined logPow of the substance is 2.5 at 23°C and pH 10..
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 2.5
- at the temperature of:
- 23 °C
Additional information
Determined according to the guideline EU Method A.8 (Partition Coefficient), the logPow of the substance was 2.5 at 23°C. Analysis was performed via HPLC.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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