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Diss Factsheets
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EC number: 403-960-2 | CAS number: 126877-05-2 C.I. DISPERSE RED 367
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: see attached file
- GLP compliance:
- yes
Test material
- Reference substance name:
- 2-ethoxyethyl-2-(4-(2,6-dihydro-2,6-dioxo-7-phenyl-1,5-dioxaindacen-3-yl)phenoxy)acetate
- EC Number:
- 403-960-2
- EC Name:
- 2-ethoxyethyl-2-(4-(2,6-dihydro-2,6-dioxo-7-phenyl-1,5-dioxaindacen-3-yl)phenoxy)acetate
- Cas Number:
- 126877-05-2
- Molecular formula:
- C28H22O8
- IUPAC Name:
- 2-ethoxyethyl 2-(4-{5,11-dioxo-12-phenyl-4,10-dioxatricyclo[7.3.0.0³,⁷]dodeca-1(12),2,6,8-tetraen-6-yl}phenoxy)acetate
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- test sample reference: NBW 8809/52
Form : red powder
Moisture content : < 0.2% water
CTL sample reference number : Y04203/002/00l
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Wistar-derived albino rats (Alpk:APfSD strain)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Animal Breeding Unit, ICI Pharmaceuticals, Alderley Park, Macclesfield, Cheshire, UK.
- Age at study initiation: young adults
- Weight at study initiation: 211-260g for males and 171-194g for females
- Housing: suspended cages (37cm length x 32cm width x 20cm height)
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- corn oil
- Doses:
- single oral dose of 2 000 mg/kg
- No. of animals per sex per dose:
- Five male and five female
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: once within 2 hours of dosing and again between 4 and 7 hours after dosing. Observations were then made once daily, or twice daily whenever there were signs of toxicity, up to Day 15.
- Frequency of weighing: on the day before dosing (Day -1), the day of dosing (Day 1) and on Day 3, Day 6 , Day 8 and Day 15.
- Necropsy of survivors performed: yes
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- None of the animals died.
- Clinical signs:
- other: No significant signs of toxicity were seen in any of the animals.
Any other information on results incl. tables
No significant signs of toxicity were seen in any of the animals. On Day 2 all the male rats were totally stained red. From Day 3 to the end of the study (Day 15) red staining was seen on the tail area only, although one animal remained totally stained up to Day 4. These observations wereattributed to the dye properties of the test sample. One female showed slight signs of urinary incontinence on Day 1.
No macroscopic abnormalities were detected at necropsy.
Applicant's summary and conclusion
- Conclusions:
- Five male and five female rats each received a single oral dose of 2000mg/kg of the Substance in corn oil. The animals were observed and
weighed during the following fourteen days.
There were no deaths and no significant signs of toxicity were seen in any of the animals. The estimated oral median lethal dose was in excess of
2000 mg/kg to both male and female rats - Executive summary:
LD 50: >2000mg/kg
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