Registration Dossier
Registration Dossier
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EC number: 204-557-2 | CAS number: 122-60-1
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1954 - 1956
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Scientific publications and secondary literature with restrictions compared to Guideline Study (limited documentation)
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- MAK Begründung: Phenylglycidylether
- Author:
- German MAK Kommision
- Year:
- 1 991
- Bibliographic source:
- MAK Begründung: Phenylglycidylether
- Report date:
- 1991
- Reference Type:
- publication
- Title:
- The toxicology of glycidol and some glycidyl ethers
- Author:
- Anderson, H. H. Dunlap, M. K. Hine, C. H. Kodama, J. K. Wellington, J. S.
- Year:
- 1 956
- Bibliographic source:
- Anderson, H. H., M. K. Dunlap, et al. (1956). The toxicology of glycidol and some glycidyl ethers. Archives of industrial health 14(3): 250-264.
- Reference Type:
- publication
- Title:
- Evaluation of acute toxicity of phenyl glycidyl ether with special regard to percutaneous absorption
- Author:
- Czajkowska, T., J. Stetkiewiez
- Year:
- 1 972
- Bibliographic source:
- Med. Pracy 23, 363 (1972)
- Reference Type:
- publication
- Title:
- Range-finding toxicity data: list V.
- Author:
- SMYTH HF Jr, CARPENTER CP, WEIL CS, POZZANI UC.
- Year:
- 1 954
- Bibliographic source:
- AMA Arch Ind Hyg Occup Med. 1954 Jul;10(1):61-8. PubMed PMID: 13170838.
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- no
Test material
- Reference substance name:
- Phenylglycidylether
- IUPAC Name:
- Phenylglycidylether
- Details on test material:
- CAS: 122-60-1
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: Albino
- Details on test animals or test system and environmental conditions:
- no data
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Amount / concentration applied:
- 0.2 mL
- Duration of treatment / exposure:
- 1 hour
- Observation period:
- 1 week
- Number of animals:
- 6
- Details on study design:
- Skin irritation on rabbits was recorded in a 10-grade ordinal series.
Grade 1 indicates the least visible capillary injection from undiluted chemical.
Grade 6 indicates necrosis when undiluted.
Grade 10 indicates necrosis from a 0.01 % solution.
Results and discussion
In vivo
Results
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: day 4
- Score:
- > 5
- Irritant / corrosive response data:
- At day 4 of the daily treatment strong erytma and edema have been reported without further details.
Applicant's summary and conclusion
- Interpretation of results:
- irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
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