Registration Dossier
Registration Dossier
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EC number: 225-059-1 | CAS number: 4635-59-0
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: early study report, essential details given
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
- Report date:
- 1973
Materials and methods
- Principles of method if other than guideline:
- according to BASF-internal standard
- GLP compliance:
- no
Test material
- Reference substance name:
- 4-chlorobutyryl chloride
- EC Number:
- 225-059-1
- EC Name:
- 4-chlorobutyryl chloride
- Cas Number:
- 4635-59-0
- Molecular formula:
- C4H6Cl2O
- IUPAC Name:
- 4-chlorobutanoyl chloride
- Details on test material:
- Name of the test substance used in the study report: gamma-Chlorbuttersäurechlorid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: intact skin
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated skin of the same animal
- Amount / concentration applied:
- ca. 1 ml
- Duration of treatment / exposure:
- 1 min, 5 min, 15 min, 20 h
- Observation period:
- 3 days
- Number of animals:
- 2
- Details on study design:
- Patch test (length: 2.5 x 2.5 cm)
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- other: erythema score for 1 min exposure
- Basis:
- mean
- Time point:
- other: 24h - 3d
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritation parameter:
- other: erythema score for 5 min exposure
- Basis:
- mean
- Time point:
- other: 24h - 3d
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: necrosis
- Irritation parameter:
- other: erythema score for 15 min exposure
- Basis:
- mean
- Time point:
- other: 24h - 3d
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: strong necrosis
- Irritation parameter:
- other: erythema score for 20 hours exposure
- Basis:
- mean
- Time point:
- other: 24h - 3d
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: strong necrosis
- Irritant / corrosive response data:
- Due to animal welfare, the experiment was stopped after 3 days.
Applicant's summary and conclusion
- Interpretation of results:
- highly corrosive
- Remarks:
- Migrated information
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